Cell Junctions, Cell Adhesion, and theExtracellular Matrix细胞连接，细胞粘附，细胞外基质.pptVIP

下载本文档

9
0
约9.33千字
约 45页
2018-06-19 发布于福建
举报
版权申诉

Cell Junctions, Cell Adhesion, and theExtracellular Matrix细胞连接，细胞粘附，细胞外基质.ppt

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Cell Junctions, Cell Adhesion, and theExtracellular Matrix细胞连接，细胞粘附，细胞外基质

Cell Junctions, Cell Adhesion, and the Extracellular Matrix Cell adhesion The c-adherins Epithelial-mesenchymal transition In mesenchymal cells the adhesion molecules are switched off. The transition is regulated by gene regulatory components named Slug, Snal and Twist. They affect E-cadherin expression Twist suppresses E-cadherin. It is involved in malignant transformation. Cell-cell junctions signalling The level of p120-catenin regulates cell junctions Beta-catenin is involved in the wnt-signalling Flamingo may act as a G-protein-coupled receptor VE-cadherin is essential for response to VEGF selectins Cadherins, integrins, selectins and Ig-members mediate cell adhesion Cadherins, integrins and selectins are Ca-dependent, Ig-members are not. Selectins mediate cell-cell adhesion in the bloodstream They bind carbohydrates (lectins) Selectins E-Selectin P-Selectin Immunoglobulin superfamily The Ig-superfamily members mediate Ca-independent cell adhesion. ICAM and VCAM (Cellular Adhesion Molecules) bind integrins Other types may have homophilic binding Figure 19-19a Molecular Biology of the Cell (? Garland Science 2008) Structure of selectins Figure 19-19b Molecular Biology of the Cell (? Garland Science 2008) functions of selectins animation Selectins Type I transmembrane proteins containing CTLD, EGF and 2–9 complement control protein (CCP) domains. Cell adhesion. Involved in the first step (initial attachment (tethering) and subsequent movement (rolling)) of leukocyte recruitment from the blood stream into sites of inflammation and lymphatic tissues. CTLDs bind the carbohydrate sialyl LewisX (SLeX) with low affinity; different high-affinity glycoprotein ligands also identified. Binding occurs via an extended site on the CTLD; in addition to fucose binding at the primary site, electrostatic and hydrogen–bond interactions are formed with other monosaccharide moieties of SLeX L-Selectin Selectins Expressed in blood monocytes, neutrophils, T and B ly