生物可吸收降解冠脉支架研究进展.pptVIP

生物可吸收降解冠脉支架（Bioabsorbable Vessel Scarfolding, BVS）的研究进展 模拟血管模型(SAM)中的输送性 闭合状态下模架的柔软度 径向强度的变化 – BVS Cohort B 节杆覆盖率: ABSORB 6个月OCT结果 机械导控 机械导控 物质的吸收:从聚乳酸降解到乳酸代谢 猪冠状动脉安全性研究:组织学图片 (2x) ABSORB Cohort B基线病变特征/即刻成功率 (Group 1) ABSORB Cohort BIVUS随访结果(Group 1) ABSORB Cohort B 6-Month QCA 血管重建疗法 总结 全生物吸收模架有望最终解决永久性金属支架引发的少见却非常严重的晚期及极晚期临床事件 重建天然血管的完整性及功能，可望为患者提供独特的临床收益 血管重建疗法可使PCI术后的长期临床疗效更持久稳定 The 6-month QCA from the first group of patients in ABSORB Cohort B showed a late loss of 0.19mm. As can be seen in this cumulative distribution curve, the late loss in Cohort B was much lower than what was seen in Cohort A, and is approaching the late loss seen with Xience V in the SPIRIT-First trial. The steepness of the red curve also illustrates how little variability there was in the distribution of late loss. There were interesting findings with IVUS. From post-procedure to 6 months follow-up, there was a nearly 12% reduction in ‘stent’ area, which accounted for the majority of late lumen loss. This was caused by the device not maintaining radial support in the vessel for long enough. But from 6 months to two years, the lumen size increased – not as a result of positive vessel remodeling, as there was no change in vessel area measured at the external elastic lamina (EEL). Rather, the increase in lumen size was the result of a decrease in the plaque/media layer of the wall. We are not certain what the mechanism was for this finding. We will be looking to see if this phenomenon occurs again in future trials, and if so, try to gain an understanding of exactly what is happening in the vessel. But this illustrates the unique and positive things that can potentially occur by restoring the vessel to a more natural state that is unconstrained by a permanent stent. In Cohort B, reductions in ‘stent’ area were minimal, resulting in a much lower late loss at 6 months than what was seen in Cohort A. It will be interesting to see if at 2 years we once again see late lumen e