动脉粥样硬化课件_7.pptVIP

* * Atherosclerosis is a disease that develops over several decades – risk factors such as smoking, hypertension, hyperlipidemia and diabetes can promote its development.1 These risk factors are extremely common in Western communities and increasingly in the new industrialized nations: hypertension affects about 40% of adults over 40 years of age obesity affects over 50% of the adult population of the US diabetes affects up to 7% of the population in Western communities. The presence of arterial fatty streaks and fibrous plaques, which can be found in individuals in their teens and twenties, is also an indicator of risk.2 This presentation of the multiple risk factors for atherothrombosis simply highlights the importance of a disease that is the leading cause of death worldwide. References: 1. Yusuf S et al. Circulation 2001; 104: 2746–53. 2. McNamara JJ et al. JAMA 1971; 216: 1185–7. * Atherothrombosis can be an extensive vascular disease affecting the coronary, cerebral and peripheral circulation. It is a progressive, generalized disorder with many clinical manifestations – either acute or chronic and often multiple in any single patient. Stenosis in an atherosclerotic artery may give rise to angina, a transient ischemic attack (TIA) or intermittent claudication. Atherothrombosis in the coronary arteries is the major cause of acute coronary syndrome (ACS), defined as unstable angina and non Q-wave myocardial infarction. Atherothrombosis of the cerebral arteries may also result in TIA or ischemic stroke. In the peripheral arteries, thrombosis superimposed on atherosclerosis can contribute to the progression of peripheral arterial disease, producing intermittent claudication (leg pain on walking that is relieved by rest) as well as ischemic necrosis and, potentially, loss of the limb. Reference: 1. Drouet L. Cereobrovasc Dis 2002; 13(suppl 1): 1–6. 动脉粥样硬化 ——你知道多少？Atherosclerosis, AS 卫生部脑卒中筛查与防治基地 云南省第一人民医院神经内科 什么是动脉粥样硬化？ 动脉粥样硬化是一组称为动脉硬化的血