病理学课件7PPT.ppt

AIDS, neurodegenerative diseases, aberrant myocardial ischemic-reperfusion Excessive Apoptosis in Diseases 1. Acquired Immune Deficiency Syndrome —AIDS HIV infection increased Fas gene expression gp120glycoprotein expression + receptor in CD4 lymphocyte infusion of infected CD4 cell leads to syncytin formation produce tat protein (enhance Fas expression) secret TNF CD+4T- lymphocyte apoptosis AIDS 2. Cardiovascular diseases Cell death induced by ischemia-reperfusion Apoptosis Necrosis Early stage Later stage Peripheral region of infarct Center of infarct Mild ischemia Severe ischemia Chronic Acute Possible mechanism (myocardial cell apoptosis induced by ischemia-reperfusion): (1) oxidative stress; (2) calcium overload; (3) p53 gene activation; (4) death receptor Fas, TNF over expressed. Cardiovascular diseases (cont.) Cardiovascular diseases (cont.) Heart failure: Myocardial cell diminishes in pressure- overload-induced heart failure Possible mechanisms: Oxidative stress; cytokines; ischemia; hypoxia; pressure or volume overload, neural-endocrine system deregulation; Lead to myocardial cell apoptosis Apoptosis and Diseases Pathophysiology Department, Tongji Medical College, HUST Concept Major pathways Key molecules Apoptosis-related diseases Insufficient apoptosis in diseases Excessive apoptosis in diseases Coexistence of insufficient and excessive apoptosis in diseases Principles of treatment Contents History of Cell Death Research Using C. elegan as a model Apop