抗生素PPT课件（英文精品）Diffusion in nanostructures Role of interaction .ppt

Plan of the talk: Consider the simplest binding-site model Show experiments on single l-phage docking to maltoporin Introduce and explain the benefits of the diffusion model (e.g. resolve the teaser) Plan of the talk: Consider the simplest binding-site model Show experiments on single l-phage docking to maltoporin Introduce and explain the benefits of the diffusion model (e.g. resolve the teaser) Plan of the talk: Consider the simplest binding-site model Show experiments on single l-phage docking to maltoporin Introduce and explain the benefits of the diffusion model (e.g. resolve the teaser) Particle and Channel Particle and Channel Particle and Channel Particle and Channel Analytical Approach Particle and Channel Free diffusion Particle Potential in the Channel: L 2a Computer simulations Computer simulations Diffusion with sticking L 2a Channel Instead of treating a channel as a featureless “binding site” we considered single-particle dynamics inside its pore *Rectangular potential well of depth U0 occupying the entire channel * Flux: *Rectangular potential well of depth U0 occupying the entire channel Dependence of the flux on the depth (bU) and tilt (bFl/2) of the potential well: Which one is more effective? ? Introducing entropic potential Simulations: Simulations vs. Theory: Entropic Potential References: The phage story: J. Molecular Biol., 2006, 359:1447-1455. Theory: Biophys. J., 2005, 88:L7-L19; Phys. Rev. Lett., 2006, 97:020601; J. of Physics: Condensed Matter, 2007, 19:065148 J. Chem. Phys., 2007 in press. * Diffusion in nanostructures: Role of interaction potentials Sergey M. BezrukovLaboratory of Physical and Structural Biology, NICHDNational Institutes of Health  together with: V. Adrian Parsegian, Alexander M. Berezhkovskii, Philip A. Gurnev, Ekaterina M. Nestorovich, Amos B. Oppenheim, and Mathias Winterhalter Roland Benz: Asymmetry? Do you mean voltage-induced asymmetry? Alf Honigmann: Translocation or not? (A par