ⅱa分泌型磷脂酶a2在胃癌及癌前病变中表达及意义-expression and significance of ⅱ a secretory phospholipase a2 in gastric cancer and precancerous lesions.docx

was not difference of the ⅡA sPLA2 expression between the specimens with Hpinfection and without Hp infection(P0.05). In AGC group, the microvessel density of the specimens with higher ⅡA sPLA2 expreesion levels was less than that with lower expression levels (P0.05). The positive expression of ⅡA sPLA2 decreasedremarkably in AGC with pelvic lymph node metastasis or chorion invasion(P0.05). Otherwise, the expression of ⅡA sPLA2 in AGC was not correlated with age, gender, tumor location or histological grading(P0.05). And moreover, the patients withhigher levels of ⅡA sPLA2 expression had significantly extended survival(P0.05).Cox model analysis showed that chorion invasion, gender and lower ⅡA sPLA2 expreesion were the independent prognostic factors for the patients with AGC. Conclusion: The loss expression of ⅡA sPLA2 may be an early event during thepathogenesis of the gastric cancer and was not correlated with Hp infection. The expression level of ⅡA sPLA2 was relevant with the formation of microvessels in the mesemchymal of gastric cancer, and the drop of the ⅡA sPLA2 expression may be enhance the microvessel formation of the gastric tumor. The loss expression of ⅡA sPLA2 may participate in the invasion and metastasis of gastric cancer. The ⅡAsPLA2 expression level was related with the survival of the patients with gastric cancer, it would disirable to become an ideal marker to evaluate the prognosis of patients.Key words: gastric cancer; phospholipase A2; helicobacter pylori; microvessel; prognosis英文缩略语英文缩略语英文全称中文全称ⅡA sPLA2secretory phospholipase A2 group ⅡAⅡA 分泌型磷脂酶 A2 HpHelicobacter Pylori幽门螺杆菌AGCadvanced gastric cancer进展期胃癌NGMnormal gastric mucosa正常胃黏膜IMintestinal metaplasia肠化DYSdysplasia不典型增生PLA2phospholipase A2磷脂酶 A2COXcyclooxygenase环氧合酶LOXlipoxygenase脂氧合酶APCadenomatous polyposis coli腺瘤样息肉WHOWorld Health Organization世界卫生组织IARCThe International Agency for Research on Cancer国际癌症研究中心MMPsmatrix metalloproteinases基质金属蛋白酶 VEGFvascular endothelial cell growth fact