多西他赛联合奥沙利铂治疗晚期头颈部恶性肿瘤.docVIP

多西他赛联合奥沙利铂治疗晚期头颈部恶性肿瘤 肿瘤预防与治疗2011年第24卷第4期 多西他赛联合奥沙利铂治疗晚期头颈部恶性肿瘤 刘鸿,李雪荣,康力,黄玲 (成都市第七人民医院,成都610041) ? 157? [摘要]目的:观察多西他赛联合奥沙利铂治疗晚期头颈部肿瘤的疗效及不良反应.方法:52例晚期头颈 部肿瘤患者按住院号随机分为A组26例和B组26例.A组多西他赛75mg/m2,静脉滴注,第1天;奥沙利铂 130mg/m2,静脉滴注,第1天;3周为1周期,连用2周期～4周期.B组顺铂25mg/m2,静脉滴注,第1天～3天;5. 氟脲嘧啶3.5g/m2,用输液泵连续滴注5天;3周为1周期,连用2周期～4周期.两组均在化疗结束2周后评价疗 效.结果:52例均可评价疗效,每例患者均完成2周期以上化疗.有效率A组为53.8%(14/26),B组为42.3% (11/26),两组差异无统计学意义(Pgt;0.05).1年生存率A组为42.3%,B组为30.8%,两组差异无统计学意义 (Pgt;0.05).生活质量提高A组50.0%(13/26),B组26.9%(7/26),两组差异有统计学意义(Plt;0.05).骨髓抑 制发生率两组差异无统计学意义(Pgt;0.05).胃肠道反应A组较B组低(Plt;0.05).结论:多西他赛联合奥沙利 铂方案治疗晚期头颈部肿瘤的缓解率较高,而毒性相对较低. [关键词]头颈部肿瘤;多西他赛;奥沙利铂;治疗 [中图分类号]R739.91;R730.53[文献标识码]Adoi:10.3969/j.issn.1674-0904.2011.04.006 DocetaxelplusOxaliplatinintheTreatmentofAdvancedHeadandNeckCancer LIUHong,LIXue—rong,KANGLi,etal (TheSeventhPeople’SHospitalofChengdu,Chengdu610041,China) [Abstract]Objective:Toobservetheeffectsandsideeffectsofdocetaxelcombinedwithoxaliplatinintreatmentofadvanced headandnecktumors.Methods:52patientswithadvancedheadandneckcancerwererandomlydividedintoAgroup(26cases)and Bgroup(26cases),Agroupaccepteddoeetaxel75rag/mintravenouslyonday1,oxaliplatin130me,/m2intravenously,day1,every 3weeksas1cycle,totally2to4cycles;Bgroupacceptedcisplatin25mg/mintravenously,dl～d3,fluorouraeil3.5g/m2,continu- OUSinfusionwithinfusionpumpfor5days,3weeksas1cycle,altogether2to4cycles.Effectwasevaluatedtwoweeksaftertreatment. Results:52caseswereavailableforeachpatientcompletedatlasettwocyclesofchemotherapy.EfficacyofAgroupWas53.8%f14/ 26),Bgroup42.3%(11/26)(Pgt;0.05).1-yearsurvivalrateofAgroupwas42.3%,Bgroup30.8%(尸gt;0.05).Lifequality of50.O%(13/26)ofpatientsinAgroupimprovedwhileinBgroup26.9%(7/26)improved(Plt;0.05).ThereWasnosignificant differenceoftheincidenceofmyelosuppressionbetweentwogroups(Pgt;0.05).ThegastrointestinalsideeffectofAgroupwaslower thanthatofBgroup(Plt;0.05).Conclusion:Docetaxelplusoxaliplatinregimencangethighrimissionrateinthetreatment0fad- v~cedheadandnecktumorswithmildtoxity. [Keywords]He