新型新烟碱类化合物的合成﹑生物活性分析及杀菌剂噁醚唑的合成工艺分析-synthesis and biological activity analysis of novel neonicotinoid compounds and synthesis process analysis of fungicide oxadiazole.docx

analyzed preliminarily. The reaction mechanism and the better synthetic methods were discussed.The bioactivity results showed that some compounds showed certain insecticidal and fungicidal activity. At the same time, fungicide is the indispensably important part in the pesticide. Triazole fungicide is given more attention because its characteristics of high-efficient, low toxicity, wide table, security and environmental protection. Difenoconazole is a new triazole fungicide. It possesses good properties of high efficiency,low poison, better environment safety, quick in preliminary effect, long in effective persistency, high internal absorbability, and showing no mutual anti-effect. The synthesis routes of new triazole fungicide difenoconazole have been discussed and designed its industry product scheme. The factor that may affect each step is anatomized and each reaction conditions are optimized. Main intermediate and productions difenoconazole were confirmed by GC-MS, 1H NMR and IR. The technological process of industry production of difenoconazole was designed on the base of research on lab scale, and the analytical method of difenoconazole was established. It is proved that the new process we have improved having obvious economy benefit, society benefit and environment benefit is suitable for the synthesis of difenoconazole. The new process we have researched has several advantages: low cost, high purity and higher yield, manipulate easily, low energy sources, and its environment benefit is remarkable. As the protection of global environment in these days, it is a great attraction for enterprise of fungicide. KEY WORDS: nicotinic derivatives; biological activity; difenoconazole; synthesis 新型新烟碱类化合物的合成﹑生物活性研究及杀菌剂噁醚唑的合成工艺研究 新型新烟碱类化合物的合成﹑生物活性研究及杀菌剂噁醚唑的合成工艺研究 青岛科技大学研究生学位论文 青岛科技大学研究生学位论文 108 108 PAGE PAGE 1 独创性声明 本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得 的研究成果。尽我所知，除了文中特别加以标注和致谢中所罗列的内容以 外，论文中不包含其他人已经发表或撰写过的研究成果，也不包含本人已 用于其他学位申请的论文或成果。与我一同工作的同志对本研究所做的任 何贡献均已在论文中做了明确的说