芭提雅足疗养生会所所属行业ppt课件.pptVIP

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芭提雅足疗养生会所所属行业ppt课件.ppt

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芭提雅足疗养生会所所属行业ppt课件

H. HogenEsch, 2009 Effector functions of antibodies Neutralization Opsonization Complement activation H. HogenEsch, 2009 Physical properties of immunoglobulins H. HogenEsch, 2009 IgM Membrane-bound monomer and secreted pentamer. First immunoglobulin to be synthesized during ontogeny and in the immune response. Activates complement pathway; agglutination. Can be transported into mucosal secretions. H. HogenEsch, 2009 IgG Highest concentration in serum. Four subclasses: IgG1 - 4 Activates complement Binds to Fcg -receptors on neutrophils, macrophages and NK cells H. HogenEsch, 2009 IgA Usually dimer Secretory IgA is a dimer with a secretory component. Two subclasses: IgA1 and IgA2 Major immunoglobulin in mucosal secretions Neutralization; Prevents binding of micro-organisms to receptors Not effective activator of complement H. HogenEsch, 2009 IgE Very low serum concentration in healthy individuals. Concentration is higher in patients with helminth infections and often in patients with allergies. Lacks hinge region; extra CH domain Binds to Fce receptor on mast cells and basophils. Cross-linking results in degranulation and release of pro-inflammatory mediators. H. HogenEsch, 2009 IgD Very low concentration in serum Primarily found with IgM on na?ve mature B cells Function is unknown H. HogenEsch, 2009 Functions of immunoglobulins H. HogenEsch, 2009 H. HogenEsch, 2009 Rituximab in autoimmune disease(pemphigus vulgaris) Ahmed et al. NEJM, 355, 1772, 2006 Rituximab + IVGG Approximate cost: $3,976 per infusion or $15,904 for a four-dose course H. HogenEsch, 2009 Immunoassays Precipitation assay Agglutination assay Enzyme-linked immunosorbent assay (ELISA) Radioimmunoassay (RIA) Western blotting Immunofluorescence Flow cytometry H. HogenEsch, 2009 Sensitivity of immunoassays precipitation - 30 mg/ml agglutination - 1 mg/ml radioimmunoassays, ELISA - 1 pg/ml H. HogenEsch, 2009 Precipitation reaction Aggregates formed by interaction of multivalent antibodie