药用天然产物全合成四川大学博士考试（英文版）.pptVIP

课程主要内容： 课程讲授药用天然产物全合成，着重强调天然产物骨架的有效构建方法，如何从小分子片断或从结构相关的、资源丰富的天然产物合成结构复杂的天然药物。授课内容包括如下四个部分：1) 药用吲哚生物碱的合成；2)头孢类抗生素合成及新药研发的一般程序；3) 药用大环多肽的合成；4) 异戊二烯类天然产物的生物合成。  课程进度安排: 第一周：药用吲哚生物碱慨述。第二周至第三周：长春花碱的合成。第四周：马钱子碱和利血平的合成。第五周至第八周：头孢类抗生素合成及新药研发的一般程序。第十周：天然环肽的分离、纯化和结构鉴定。第十一周：环肽的合成方法学。第十二周至第十三周：药用天然环肽的合成。第十四周：C5单元的合成及组合。第十五周：单萜、倍半萜和二萜的合成。第十六周至第十七周：二倍半萜、三萜和类胡萝卜素的合成。? Syntheses of Natural Medicines General Introduction of Indole Alkaloids Structurally most diverse natural product, over 5000 has been identified Most from plant kingdom, also from fungi，insects and mammals Long historic usage: Traditional Chinese medicines; Poisons for hunting, murder; euphoriants, psychedelics and stimulants in religious activities; drug abuse-serious social problem Human interest-Pharmacological activities, lead compounds to synthetic analogue-drugs Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Syntheses of Natural MedicinesStructural Summaries of Medicinal Indole Alkaloids Synthetic Challenge Molecules Synthesis of Vinblastine P. Potier et al. J. Am. Chem. Soc. 1979, 101, 2243； M. E. Kuehne et al. J. Org. Chem. 1991, 66, 1560； P. Magnus et al. J. Am. Soc. Chem. 1992, 114, 10232； T. Fukuyama et al. J. Am. Soc. Chem. 2002, 124, 2137 Synthesis of VinblastineP. Potier et al. J. Am. Chem. Soc. 1979, 101, 2243 Synthesis of VinblastineP. Potier et al. J. Am. Chem. Soc. 1979, 101, 2243 Synthesis of VinblastineP. Potier et al. J. Am. Chem. Soc. 1979, 101, 2243 Synthesis of VinblastineP. Potier et al. J. Am. Chem. Soc. 1979, 101, 2243 Synthesis of VinblastineCatharanthine Synthesis Catharanthine Synthesis B. M. Trost et