假体周围磨损颗粒诱导骨溶解钙调磷酸酶,活化T细胞核因子信号通路作用的研究进展.docVIP

假体周围磨损颗粒诱导骨溶解：钙调磷酸酶/活化T细胞核因子信号 通路作用的研究进展 张云鸽，宋科官(哈尔滨医科大学附属第一医院骨三科，黑龙江省哈尔滨市 150001) 引用本文：张云鸽，宋科官. 假体周围磨损颗粒诱导骨溶解：钙调磷酸酶/活化T细胞核因子信号通路作用的研究进展[J].中国组织工程研究，2017，21():1115-1122. DOI:10.3969/j.issn.2095-4344.2017.07.024 ORCID: 0000-0001-9877-5485(张云鸽) 文章快速阅读： 文题释义： 钙调磷酸酶：活化T细胞核因子(NFAT)：通路正是与Ca2+信号和核因子κB受体活化因子配体参与破骨细胞分化相关的信号传导通路。破骨细胞和胞核因子κB受体活化因子配体分别在骨吸收的生理病理过程中及破骨细胞生成过程中发挥关键作用。 Periprosthetic osteolysis induced by wear particles: research progress of calcineurin/activated T cell nuclear factor signaling pathway Zhang Yun-ge, Song Ke-guan (Third Department of Orthopedics, First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, China) Abstract BACKGROUND: Periprosthetic osteolysis and subsequent aseptic loosening are most common reasons for revision after total joint replacements. Recently studies found that calcineurin/activated T cell nuclear factor (CN/NFAT) signaling pathway plays important roles in the pathogenic process of wear-induced inflammation and osteolysis. OBJECTIVE: To summarize CN/NFAT effects on wear particles-induced osteolysis, and to provide new ideas and new theories for osteolysis-related diseases. METHODS: We retrieved PubMed for studies published from January 1980 to June 2016. The key words were “CN/NFAT, CN/NFAT signaling pathways, wear particles, osteolysis, osteoclasts, osteoblast”. Finally, 72 studies were analyzed and explored according to inclusion and exclusion criteria. RESULTS AND CONCLUSION: The pathogenesis of osteolysis involves the activation of macrophages by wear particles and the release of various proinflammatory cytokines. Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts and osteoblasts. In this process, CN/NFAT signaling pathway is the signal transduction pathway involved in the differentiation of Ca2+ and nuclear factor kappa B receptor ligand. Os