化疗方案手册英文版050608-color-matrixcancerstagingandtreatment.docVIP

Color-Matrix Cancer Staging and Treatment Handbook Edwand H.Lin,MD· Richard Lozano,RPh· Daniel D,Karp,MD THE UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER Making Cancer History Third Edition 2004 【仅选取化疗方案部分】 AIDS-Related Kaposi’s Sarcoma Drug Dose and Schedule Liposomal Daunorubicin Liposomal daunorubicin (DaunoXome) 40mg/m2 IV over 60 minutes Repeat every 14 days. Liposomal Doxorubicin Liposomal doxorubicin (Doxil) 20mg/m2 IV over 60 minutes Repeat every 21 days. Paclitaxel Paclitaxel 135mg/m2 IV over 3 hours Repeat every 21 days. or Paclitaxel 135mg/m2 IV over 1 hours Repeat every14 days. Breast Cancer-Adjuvant Therapy Regimen Drug Doses and Schedules DFS Rate OS Rate Grade 3 and 4 Side Effects; Reference(s) FAC Fluorouracil 500 mg/m2 IV days 1 and 4 Doxorubicin 50 mg/m2 CI over 72 hours Starting day 1 Cyclophosphamide 500 mg/m2 IV day 1 Repeat every 21 days for 6 cycles. 63% at 7 yr (stage ll) 69% at 7 yr (stage ll) Neutropenia,Mucositis, Nausea or vomiting, Neutropenic fever Buzdar A. In:salmon SE, ed. Adjuvant Therapy of Cancer Vll. Philadeophia, Lippincott,1993. Cancer 53:384, 1984. Sequential Paclitaxel→ FAC Paclitaxel 80 mg/m2 IV over 1 hours Weekly for 12 weeks followed by FAC (as above) for 4 cycles 86% at 48 mo Too early Neutropenia, Mucositis, Nausea or vomiting, Neutropenic fever Clin Cancer Res 8:1073, 2002 FEC Fluorouracil 500 mg/m2 IV day 1 Epirubicin 100 mg/m2 IV day 1 Cyclophosphamide 500 mg/m2 IV day 1 Repeat every 21 days for 6 cycles. 66.3% at 5 yr 50.7% at 10 yr 77.4% at 5 yr 54.8% at 10 yr Neutropenia,Mucositis, Nausea or vomiting, Neutropenic fever J Clin Oncol 19:602, 2001 Proc Am Soc Clin Oncol A93, 2003 CEF* Cyclophosphamide 75mg/m2 PO days 1-14 Epirubicin 60 mg/m2 IV day 1 and 8 Fluorouracil 500 mg/m2 IV days 1 and 8 Repeat every 21 days for 6 cycles. *Requires prophylactic antibiotics or growth factor support. 63% at 60 mo(vs 53% for CMF) 52% at 10 yr (vs 45% for CMF) 77% at 60 mo(vs 70% for CMF) 62% at 10 yr (vs 58% for CMF)