新释药系统研究进展-张强推荐.pptVIP

* 载体给药系统 重要提示 也是释药系统研究开发的主要发展方向之一 最有可能实现靶向给药 * 前体药 实例: 新抑癌菌素-苯乙烯马来酸 PEG-干扰素、PEG-腺苷脱氨酶、PEG-天冬酰氨酶等 Insulin (levemir) DHA-paclitaxel (Taxoprexin):III Methorexate-albumin:I/II DOXO-EMCH:I/II GLP-1-albumin:I/II Interferon-albumin fusion protein(Albuferon): III * 前体药 重要提示 由于母体药物已用于临床，疗效肯定，研究成功率相对较高 开发成本低,时间短,风险小 * 谢 谢 ！ * * The U.S. Food and Drug Administration recognizes 111 distinct routes of administration. The following is a brief list of some routes of administration. * 肿瘤死亡率世界第一，化疗是最用的治疗方法，但化疗对生命周期延长的贡献很小,2% life span is only 10 days. * * * 主要目的不是PK,而是毒性,但说有靶向性? * 亲水/脂性基团:改变理化性能,改变体内过程 亲水高分子:长效化,如PEG化; 部位特异性酶的利用:靶向性，降低毒性 特有化学反应的利用(含二硫键)：靶向性，降低毒性 * PK与剂型的关系! * 新释药系统研究进展Advances in drug delivery systems 张 强 北京大学药学院  Topical epicutaneous (application onto the skin), e.g. allergy testing, typical local anesthesia inhalational, e.g. asthma medications enema, e.g. contrast media for imaging of the bowel eye drops (onto the conjunctiva), e.g. antibiotics for conjunctivitis ear drops - such as antibiotics and corticosteroids for otitis externa intranasal route (into the nose), e.g. decongestant nasal sprays. Nasal administration can also be used for systemic effect. vaginal, e.g. topical estrogens, antibacterials Enteral Enteral is any form of administration that involves any part of the gastrointestinal tract: by mouth (orally), many drugs as tablets, capsules, or drops by gastric feeding tube, duodenal feeding tube, or gastrostomy, many drugs and enteral nutrition rectally, various drugs in suppository or enema form Parenteral by injection or infusion intravenous (into a vein), e.g. many drugs, total parenteral nutrition intraarterial (into an artery), e.g. vasodilator drugs in the treatment of vasospasm and thrombolytic drugs for treatment of embolism intramuscular (into a muscle), e.g. many vaccines, antibiotics, and long-term psychoactive agents intracardiac (into the heart), e.g. adrenaline during cardiopulmonary resusc