comparing models of sleep-dependent memory consolidation：睡眠相关记忆整合模式之比较精品.pdfVIP

J Exp Clin Med 2010;2(4):156–164 RE VIE W ARTICLE Comparing Models of Sleep-dependent Memory Consolidation 1 2 Sara C. Mednick *, William A. Alaynick 1 Department of Psychiatry, University of California, San Diego, San Diego, California, USA 2ScholarNexus, LLC, San Diego, California, USA Received: Mar 5, 2010 The enhancement of normal cognition and breakthrough treatments in cognitive disorders Revised: Apr 25, 2010 require an improved understanding of memory consolidation. Insights into the mechanisms Accepted: May 2, 2010 of memory consolidation have been advanced by the incorporation of a quantifiable variable: sleep. Over the past 20 years, a substantial number of studies have shown that memory KEY WORDS: performance is facilitated after a bout of sleep, compared with the same period of waking, declarative memory; implicating a slow, offline process during sleep that transforms the memory trace into a more robust form through a consolidation process. Until recently, the majority of these GABA; studies have examined cognitive tasks that utilize non-declarative, procedural memory hippocampus; (e.g., knowing “how”, learning actions, habits, perceptual and motor skills, and implicit implicit memory; learning) to show enhanced performance above baseline. Recent attention has turned to memory; studying the relationship between sleep and