田七中分离的皂苷具有细胞凋亡作用.pdfVIP

Medicinal Chemistry , 2007, 3, 51-60 51 Isolation, Structural Determination, and Evaluation of the Biological Ac- tivity of 20(S)-25-methoxyl-dammarane-3, 12, 20-triol [20(S)-25-OCH3- PPD], a Novel Natural Product from Panax notoginseng 1,2,† 1,† 2 1 1,4 1,3,4 1,3, 4,* Y. Zhao , W. Wang , L. Han , E.R. Rayburn , D.L. Hill , H. Wang and R. Zhang 1Department of Pharmacology and Toxicology and Division of Clinical Pharmacology, University of Alabama at Bir- mingham, Birmingham, AL 35294, USA, 2Shenyang Pharmaceutical University, Shenyang 110016, P. R. China, 3Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Shanghai 200031, P. R. China and 4 Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA Abstract: Ginseng has been used extensively for medicinal purposes, with suggested utility for indications as diverse as diabetes, cardiovascular disease and cancer. Herein we report the discovery and characterization of 20(S)-25-OCH3-PPD, a ginsenoside that inhibits growth and survival of cancer cells. The novel dammarane triterpene sapogenin (C H O ; mo- 31 56 4 lecular weight 492) was isolated from the total hydrolyzed saponins extracted from the leaves of Panax notoginseng using conventional and reverse-phase silica gel chromatography. Based on physicochemical characteristics