整数非线性规划模型在乳腺癌转移相关基因表达调控网络建立中的应用.pdfVIP

27 2 Vo.l 27 No. 2 2008 4 Beijing B iomed ical Engineering Apri l 2008 整数非线性规划模型在乳腺癌转移相关基因 表达调控网络建立中的应用 1 1 1 2 罗万春 易东 刘恩 龚利红 , , LINGO8. 0 MATLAB7. 0 , 27, 25, 11 , ; ; R318. 04 A 1002-3208(2008) 02-0138-04 The application of I NLP m odel in setting up the regulary networks of gene related to breast cancerm etastasis 1 2 3 4 L UO Wanchun , YI D ong , L I U E n , GON G L ihong 1Th ird M ilitary M ed ical Un iv er sity, Chongq ing 400038 2D ep art- men t of M ach ine and E lectron, Chong qing C omm un ica tion C olleg e, Chongq ing 400035 =Abstract The authors u tilized the entropy inform ation from genetic data of breast cancer metastas is to get the w eights of all the genes, and set up an in teger non linear program ing ( INLP) m odel inwh ich m in mi um error is regarded as objective function to search for the regulary relation in the genes, and then s ieved regulary genes by coefficient correlation m odel. Using the program s of LINGO8. 0 and MATLAB7. 0, w e got a genetic regu lary network of the 27 genes related to breast cancerm etastasis, where there are 25 pairs genes exiting regu lary relation and 11 pairs genes beingm utual prom otion effect. INLP can describe the regulary relation of genes related to breast cancerm etastasis, and can be used to studym ore com plicated genetic regulary newt ork. =Key words b reast cancer; genetic regulatory newt orks; INLP , , , ; , , ,