【体外膜肺ECMO精品课件】 Hantavirus.ppt

Hantavirus;What is Hantavirus?;Old World Hantavirus vs New World Hantavirus;The History of Hantavirus;Virus of Wars?;Those smart Japanese doctors…;Is it the mouse?;Meanwhile…..;“Hanta” virus;Hantavirus in America;The mysterious illness;The CDC;Those smart Navajo elders….;Human to human transmission?;Figure 1. Transmission tree for HPS cases in southern Argentina, September-December 1996, indicating dates of onset of symptoms, survivor status, and proposed lines of transmission. Lines of transmission are hypothetical since many of the patients had contact with multiple HPS patients. Bold lines denote husband and wife. The two sporadic cases, U and R, are not shown. ; ?????????????????????????????????????????????Figure 2. Towns involved in the 1996 HPS outbreak in southern Argentina. ;Hantavirus: HFRS;Hantavirus: HPS;Hantavirus: HPS;Tracking HPS in the United States (1993 till 2001);HPS Statistics as of March 28, 2002;Topics of Molecular Biology;Family: Bunyaviridae;Bunyaviridae Family;23 Well-described Hantaviruses;Virus is Rodent-specific;;Physical Properties of Virion;Viral Genome;Panhandle Structure;Protein Products;Protein Products Cont’d;Transcription: Viral Entry;Transcription and Translation;Replication;Prime and Realign Model;Prime and Realign Model Cont’d;Virion Assembly;Virion Release and Persistence;The Big Picture;Pathogenesis;?3 Integrins and Pathogenesis;?3 Integrins;Immune Response Pathogenesis;Rodent Hosts and Epidemiology;Rodent Hosts in the United States;White-footed Mouse (Peromyscus leucopus);Cotton Rat (Sigmodon hispidus);Rice Rat (Oryzomys palustris);Rodent Transmission;From Rodent to Human;Person-to-Person Transmission;Summary;Topics;Clinical Manifestations:;Stages of Hemorrhagic Fever with Renal Syndrome (HFRS);HFRS: Febrile Phase;HFRS: Hypotensive phase;HFRS: Oliguric Phase;HFRS: Recovery;Nephropathia Epidemica (NE);Stages of Hantavirus Pulmonary Syndrome (HPS);HPS: Febrile phase;HPS: Cardiopulmonary Phase;HPS;HPS;HPS;HPS: Different