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T cell development within the intestinal--T细胞在小肠内的发展和繁衍
Pergamon Advances in Neuroimmunology Vol.6, pp. 397-405, 1996 © 1997Elsevier ScienceLtd.All rights reserved Printed in GreatBritain 0960-5428/96 $32.00 PII: S0960-5428(97)00032-0 T cell development within the intestinal mucosa: clues to a novel immune-endocrine network? J o h n R. Klein Department of BiologicalScienceand the MervinBovairdCenterfor Studiesin MolecularBiologyand Biotechnology, University of Tulsa, Tulsa. OK 74104,USA Keywords--Intraepithelial lymphocytes,extrathymicT cell development, immune-endocrineinteractions, intestine, thy- mopoiesis, endocrine-paracrineregulation. Summary Small intestine intraepithelial lymphocytes (IELs) The intestinal immune system is comprise a heterogeneous and phenotypically distinguished by novel phenotypic and complex population of T cells that are part of the functional properties gut-associated lymphoid tissues (GALTs). Recent In addition to its role in digestion and absorption, studies from a number of laboratories indicate the intestinal mucosa constitutes a major host that murine IELs are greatly enriched for extrath- barrier to foreign antigen entry. It is not surpris- ymic T cells, although many aspects of the IEL ing, therefore, that the intestinal immune s
有哪些信誉好的足球投注网站
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