BRUCELLOSIS[布鲁氏菌病](PPT-35).pptVIP

BRUCELLOSIS Historical Background Malta Fever Major health problem to British troops in Malta in the 19th and early 20th centuries. Historical Background 1860 J.A. Maraston; assistant surgeon in the British Army in Malta -- first accurate description “Mediterranian Gastric Remittent Fever” David Bruce (1855-1931) -1883 sent to Malta to provide medical care to the troops. - 1887 isolated “micrococcus” from spleens of 4 soldiers died of the disease. Historical Background 1897 A.E. Wright ; pathologist in British army - developed agglutination test. What is the source? “Mediterranean Fever Commission” 1904 Historical Background 1905 Zammit; Maltese physician - Goats were the source of infection. 1897 E. Bang; Danish veterinarian -described intracelular pathogen causing abortion in cattle named “Bacillus abortus”. 1918 A. Evans; American microbiologist -made the connection between Bacillus abortus and micrococcus melitensis named it Bacteriaceae. Historical Background 1920 Meyer and Shaw suggested BRUCELLA 1914 Mohler isolated organism from liver spleen of Pigs--B.suis. 1957 B. neotome, 1963 B. ovis, 1966 B. canis Epidemiology Worldwide zoonosis Only 17 countries declared brucellosis free1986 Six species 1. B.abortus - mainly cattle 2. B.melitensis - sheeps goats 3. B.suis - pigs 4. B. canis - dogs 5. B. ovis - sheep (not human pathogen) 6. B. neotomae - desert wood rat (not human pathogen) B. melitensis -- most common worldwide Epidemiology in Saudi Arabia Endemic disease Mostly B. melitensis b. abortus. No clear figures about incidence prevalence. Incidence : 5.4 per 1000 per year. Prevalence : 8.6 - 38 % - some regions. Bacteriology Gm - ve cocci, coccobacilli, bacilli. Strict aerobic, nonmotile, nonspore forming. B. ovis, B. abortus --CO2 supplementation