牛磺酸的合成新工艺-中国现代应用药学.PDFVIP

·药物化学 · 牛磺酸的合成新工艺 何晓强，杨成雄，李安梅(荆楚理工学院化工与药学院，湖北 荆门 448000) 摘要：目的 研究牛磺酸的合成新工艺。方法 以乙醇胺(MEA)为原料，在改性 HZSM-5 分子筛催化剂作用下，经分子 内脱水和与亚硫酸氢胺开环加成两步反应制备牛磺酸。结果 分子内脱水的适宜工艺条件是：反应温度为 425 ℃、反应 压力为常压、反应器空速为 2 300 h1、反应原料配比为 N /MEA=10 。在该条件下，乙醇胺的转化率 93.2% ，选择性 84.6% ， 2 牛磺酸的总收率为 73%( 以乙醇胺计) 。结论 新工艺优于乙醇胺酯化法(50%)和环氧乙烷法(60%),具有很好的工业化前景。 关键词：牛磺酸；乙醇胺；乙撑亚胺；合成 中图分类号：R916.42 文献标志码：A 文章编号：1007-7693(2012)01-0043-03 A New Synthesis Technology of Taurine HE Xiaoqiang, YANG Chengxiong, LI Anmei(College of Chemical Engineering and pharmacy, Jingchu University of Technology, Jingmen 448000, China) ABSTRACT: OBJECTIVE To improve the new synthetic route of taurine. METHODS Taurine was prepared from monoethanolamine (MEA) by intramolecular dehydration in the presence of HZSM-5 molecular sieve and ring-opening addition with sodium hydrogen sulfite. RESULTS The optimum reaction conditions were as follows: the reaction temperature was 425 ℃, the reaction pressure was atmospheric pressure, space velocity was 2 300 h1, the ratio of volume of N to MEA was 10. 2 By using the above conditions, the monoethanolamine conversion amounts to 93.2%, the selectivity is 84.6%, the total yield of taurine is 73% (ethanolamine). CONCLUSION This method is superior to that of esterification of monoethanolamine(50%) and ethylene oxide(60%)and it is suitable to the industrial production. KEY WORDS: taurine; monoethanolamine; ethylenimine; synthesis 牛磺酸(taurine) 的化学名称是 2-氨基乙磺酸， 合成路线见图 1。 是一种非蛋白质氨基酸，是人体内重要的氨基酸 [1] Cat NH HSO NH 之一，具有特殊的生理作用 。近几年在药用和食 NH2 4 3 2