Th17Treg细胞在支气管哮喘患者外周血中的表达 优先出版.pdf

网络出版时间：2016-08-15 08:11:37 网络出版地址：/kcms/detail/11.5784.R0811.002.html 《中国医学创新》第 13 卷 第 24 期（总第 378 期）2016 年 8月　　经验交流 Jingyanjiaoliu Th17/Treg细胞在支气管哮喘患者外周血中的 表达 ① ② ① ② ② 王君丽 　徐彦飞 　李小莉 　徐晓妮 　皮丹 　　【摘要】　目的：探讨 Th17/ 调节性 T 细胞（Treg 细胞）在支气管哮喘患者外周血中的表达及意义。 方法：收集 30 例正常对照组，30 例确诊支气管哮喘患者（哮喘组）在急性发作期及缓解期外周血，分 别检测 Th17/Treg 细胞的表达情况。 结果：支气管哮喘患者急性发作期间 Th17 较正常对照组明显升高， 而 Treg 细胞比例明显下降，支气管哮喘缓解期上述异常指标均趋于正常，但比正常对照组仍有明显改变 （ 0.05）。Th17、Th17/Treg 与支气管哮喘患者 ACQ 评分呈正相关（ 0.05），Treg 与 ACQ 评分呈负相关 P P （ 0.05），但 Th17 和 Treg 之间无明显相关性（ 0.05）。结论：在支气管哮喘患者体内的存在 Th17 及 P P Treg 细胞的平衡失调，可能参与疾病的进展，成为免疫调节治疗的靶点。 　　【关键词】 　支气管哮喘；　TH17；　调节性 T 细胞 　　Expression of Th17/Treg Cells in Peripheral Blood of Patients with Bronchial Asthma/WANG Jun-li， XU Yan-fei，LI Xiao-li，et al.//Medical Innovation of China，2016，13（24）：117-119 　　【Abstract】　Objective：To investigate the expression of Th17/Treg cells in peripheral blood of patients with bronchial asthma.Method：A total of 30 cases of normal control group and 30 cases diagnosed with bronchial asthma in acute attack and remission of peripheral blood were collected，the expression of Th17/Treg cells were detected respectively.Result：Th17 in patients with bronchial asthma during acute attack was significantly higher than that in normal control group，the proportion of Treg cells decreased significantly，in the remission stage of bronchial asthma，the abnormal indexes tended to be normal，but there was still a significant change compared with the normal control group，the differences were statistically significant（P0.05）.Th17，Th17/Treg were positively correlated with bronchial asthma patients ACQ score（P0.05），Treg was negatively correlated with ACQ score（P0.05），but there was no significant correlation between Treg and Th17（P0.05）.Conclu