难治性弱视论文：难治性弱视眼视网膜厚度分析.docVIP

难治性弱视论文：难治性弱视眼视网膜厚度分析 【中文摘要】利用光学相干断层扫描技术(OCT)检测难治性弱视眼的视网膜厚度,探讨难治性弱视是否存在视网膜形态学改变,为其发病机制的研究提供一定的理论依据。方法从青岛大学医学院附属医院眼科2010年5月-2011年4月门诊就诊的弱视患儿中选择难治性弱视眼27例30眼作为实验组,另选非难治性弱视眼22例30眼、屈光度±1.00D的同龄正常儿19例30眼作为对照组。用光学相干断层扫描仪(Opti cal Coherence Tomography OCT)对实验组和对照组患儿的黄斑区进行快速扫描,测量黄斑中心凹、中心区(1mm直径范围)及旁中心区(直径为3mm环形区域内)上方、下方、鼻侧、颞侧的平均视网膜厚度,比较不同区域视网膜厚度的差别。结果难治性弱视眼、非难治性弱视眼、正常对照眼黄斑中心凹厚度分别为198.83±32.33μm、189.57±29.59μm和178.10±29.29μm,三组比较差异均有统计学意义(P值分别为0.03、0.004、0.001,(P0.05)。难治性弱视眼、非难治性弱视眼、正常对照眼黄斑中心区平均厚度分别为225.47±19.85μm、219.93±18.55μm和213.47±28.33μm,三组比较,P值分别为P=0.03、0.045、0.001,差异也均有统计学意义(P0.05)。而黄斑旁中心区上方、下方、鼻侧及颞侧视网膜厚度,难治性弱视眼分别为298.70±27.71μm、298.63±26.36μm、298.00±31.5μm、292.27±30.04μm,非难治性弱视眼分别为300.10±25.46μm、297.33±31.04μm、298.33±34.23μm、286.57±24.87μm,正常对照眼分别为297.07±23.28μm、294.57±39.27μm、299.07±24.48μm、294.57±39.27μm,四象限区域视网膜厚度在三组之间,差异均无明显统计学意义(P0.05)。结论难治性弱视眼黄斑中心凹、中心区视网膜厚度增加,黄斑旁中心区上方、下方、鼻侧及颞侧视网膜厚度无明显改变。 【英文摘要】:To detect the retinal thickness by using Optical Coherence Tomography (OCT) in refractory amblyopia eyes,And to investigate whether the morphology of macula changes or not,then to discuss its mechanism.Method:To collect cases from out-patient in The Medical School Hospital Of Qingdao University.27cases(30 eyes) of refractory amblyopia eyes were selected as the experimental group.In addition, 22cases(30 eyes) of recovered amblyopia eyes and 19cases(30 eyes) of normal eyes with the same age (diopter?.00D) were selected as the normal control group.The children of the experimental group and the normal control group were fast-scaned by using Optical Coherence Tomography(OCT) in the macula. Average thickness of the foveola the fovea (1-mm diameter range) and the superior、inferior、nasal、temporal parafovea (the ring of 3-mm diameter) was then assessed by macular retinal tomography map measurement. Finally, the results were analyzed statistically and the retinal thickness was compared in different areas.Result:The foveola thickness of refractory amblyopia eyes、recovered amblyopi