非小细胞肺癌脑转移放疗联合替莫唑胺治疗近期疗效的观察.docVIP

精品论文 参考文献 非小细胞肺癌脑转移放疗联合替莫唑胺治疗近期疗效的观察 湖南省岳阳市一人民医院肿瘤科 湖南岳阳 414000 【摘 要】目的：探讨非小细胞肺癌脑转移应用替莫唑胺联合放疗治疗的临床疗效。方法：选取50例非小细胞肺癌脑转移患者作为研究对象，分为两组进行对照研究，其中对照组单纯采取放疗治疗，观察组在放疗治疗的基础上，应用替莫唑胺治疗；对比两组患者的生活质量改善情况、症状改善率、肿瘤缩小率及不良反应发生情况。结果：观察组生活质量上升率为95.05%、症状改善率为92.00%、肿瘤缩小率为67.14%，对照组生活质量上升率为84.84%、症状改善率为64.00%、肿瘤缩小率为42.54%；两组数据具有显著性差异（P＜0.05）；两组患者均出现不同程度的恶心或呕吐、头痛、I或II度骨髓抑制，均未出现III或IV度骨髓抑制，不良反应发生情况无显著性差异（P＞0.05）。结论：放疗联合替莫唑胺可协同提高对非小细胞肺癌脑转移的疗效，安全性好，无明显增加不良反应，对于改善患者的生活质量具有积极作用，值得临床推广使用。 【关键词】非小细胞肺癌；脑转移；替莫唑胺；放疗 Brain metastases from non-small cell lung cancer radiotherapy combined for mo thiazole amine in the near future curative effect observation Zhan Dahe Da Shijian FangFang Hunan yueyang city peoples hospital of oncology Hunan yueyang 414000 [Abstract] Objective：to study the application of brain metastases from non-small cell lung cancer for clinical curative effect of amine with radiation therapy. Methods：select 50 cases of patients with brain metastases from non-small cell lung cancer as the research object，controlled study is divided into two groups，the control group treated with radiotherapy alone，a group in radiation therapy，on the basis of application for mo thiazole amine treatment；Compared two groups of symptoms of the patients quality of life improvement，period，tumor shrink rate and adverse reactions occur. Results：observation group life quality to rise，tumor was 95.05%，symptoms period 95.05% reduced rate of 67.14%，the control quality of life rise，tumor was 84.84%，symptoms period 84.84% shrinking at a rate of 42.54%；Two groups of data has significant difference（Plt;0.05）；Two groups of patients have varying degrees of nausea or vomiting，headache，bone marrow suppression，I or II degree are not present III or IV degree of bone marrow suppression，adverse reactions to what is happening there was no significant difference（Pgt;0.05）. Conclusion：the combination of radiotherapy for mo thiazole amine synergy to improve curative effect of brain metastases from no