非小细胞肺癌淋巴道转移的MSCT表现与VEGF-C 、LVD表达关系的对照研究.docVIP

精品论文 参考文献 非小细胞肺癌淋巴道转移的MSCT表现与VEGF-C 、LVD表达关系的对照研究 刘军泉 朱卫国 刘国文 陈忠其 (佛冈县人民医院影像科 511600) 【摘要】目的:探讨非小细胞肺癌淋巴道转移的MSCT征象与VEGF-C，VEGFR-3表达的关系。方法：搜集40例经手术病理证实的非小细胞癌和18例肺良性病变，术前行MSCT扫描，术后对标本行VEGF-C，VEGFR-3免疫组化染色，分析肺癌淋巴道转移的MSCT表现与VEGF-C，VEGFR-3表达关系。结果：非小细胞癌组VEGF-C阳性率62.5%(25/40)和LVD水平(11.67plusmn;2.93)均显著高于对照组(Plt;0.01)，淋巴结转移阳性组VEGF-C阳性率90%(18/40)及LVD水平(18.54plusmn;3.28)均高于淋巴结阴性组(Plt;0.01)。结论：VEGF-C高表达与淋巴管生成及淋巴结转移存在明显相关性。 【关键词】 肺癌 血管内皮细胞生长因子—C 血管内皮细胞生长因子受体-3 淋巴管生成 淋巴结转移 【中图分类号】R734.2 【文献标识码】A 【文章编号】2095-1752（2014）18-0250-02 Relationships between quantified MSCT from the lymphatic metastasis of lung cancer and pathology/ VEGF-C expression Liu Junquan Zhu Weiguo Liu Guowen Chen Zhongqi 【Abstract】Objective: Explore the relationships between quantified MSCT from the lymphatic metastasis of lung cancer and pathology/ VEGF-C expression. Methods: Collected 40 cases of surgically excised and pathologically confirmed non-small cell lung cancer and 18 cases of benign tissue. MSCT scanned before surgery, and after surgery, specimens of VEGF-C, VEGFR-3 were collected for immunohistology staining. Then analyzed the relationships between quantified MSCT from the lymphatic metastasis of lung cancer and VEGF-C expression. Results: Non-small cell carcinoma positive rates of VEGF-C, LVD were significantly higher (P lt;0.01), and lymph node metastasis group positive rate of VEGF-C and LVD was higher than node-negative group. Conclusion: High expression of VEGF-C and lymphangiogenesis and lymph node metastasis were significantly correlated. 【Key words】Vascular endothelial growth factor-C Vascular endothelial growth factor receptor -3 Lymphangiogenesis; Lymph node metastasis 肺癌发病率高，是全世界癌症死亡的首要因素。非小细胞肺癌是最常见的肺癌，占全部肺癌的约80%。由于目前肺癌早期诊断困难， 80%的肺癌患者在确诊已处于中晚期、癌肿转移，从而失去了最佳的治疗时机，这是我国肺癌死亡率升高的主要原因[1]。淋巴道转移是非小细胞癌常见的转移途径，非小细胞癌早期易发生淋巴结转移，淋巴管生成是肺癌发生淋巴结转移的初始步骤和必需条件，而VEGF-