针对原发性甲状旁腺机能亢进性骨病CT、MRI与病理对照的实验研究.docVIP

精品论文 参考文献 针对原发性甲状旁腺机能亢进性骨病CT、MRI与病理对照的实验研究 湖南省衡东县人民医院 湖南衡阳 421400 【摘 要】目的：探讨原发性甲状旁腺机能亢进的骨骼病变CT、MRI的特征性表现，评价其应用于临床诊断的效果。方法：选取健康的成年中国白兔60只，将其随机分为干预组和基础组，基础组的30只白兔给予正常饮食喂养（饮食中钙磷比例为10：7），干预组的30只白兔给予高磷饮食（饮食中钙磷比例为1：7），持续为造原发性甲状旁腺机能亢进的动物模型。并从第3个月开始，每月对干预组和基础组动物行螺旋CT与高场MR骨扫描，对影像学特征进行分析。6个月后对所有白兔甲状旁腺标本与骨标本进行病理学检查，以此来检验影像学诊断是否准确无误。结果：基础组白兔甲状旁腺与骨骼检测均无异常。干预组标本病理检验可见甲状旁腺增生明显，骨骼有骨质疏松与骨皮质吸收表现明显，MR的T1WⅠ为程度不同的局限性低信号改变，T2WⅠ早期为程度不同的局限性低信号改变或者中等信号改变，例如骨髓水肿的表现是高信号改变，若病情进展至纤维组织替代骨组织影像学表现则改为低信号表现。螺旋CT检测分别为阴性表现、可疑表现、骨质疏松表现、骨膜下皮质吸收表现等。结论：螺旋CT结合MRI可对原发性甲状旁腺机能亢进性骨病进行检测确诊和分期，可作为早期PHPT骨骼病变的诊断和研究手段。 【关键词】磁共振；体层摄影术，X线计算机；原发性甲状旁腺机能亢进；骨病 【 abstract 】 objective：to study the bone lesions of primary hyperparathyroidism characteristic of CT，MRI，to evaluate the effect of its application in clinical diagnosis. Methods：choose healthy adult Chinese white rabbit 60，randomly divided into intervention group and foundation，its basic group of 30 white rabbit give normal diet（dietary calcium phosphorus ratio for persons），intervention group of 30 white rabbit give high phosphorus diet（dietary calcium phosphorus ratio is 1：7），continue to build the animal model of primary hyperparathyroidism. And since 3 months，monthly based group of animals to the intervention group and row spiral CT and high field MR bone scan，analyze the imaging features. After six months for all white rabbit parathyroid specimens and bone specimen for pathological examination，in order to test whether imaging diagnosis accurately. Results：the white rabbit parathyroid and skeleton detection based group were no exception. Specimens of intervention group on pathology visible parathyroid hyperplasia，bone osteoporosis and bone cortex absorption performance obviously，the T1W MR Ⅰ at different levels for the limitations of low signal change，T2W Ⅰ early limitations to different levels to alter or medium low signal change，such as the performance of the bone marrow edema is high signal change，if the disease progresses to fibrous tissue substitution bo