不同剂量地佐辛对全麻甲状腺手术后患者苏醒期与术后早期镇痛效应的影响.docVIP

不同剂量地佐辛对全麻甲状腺手术后患者苏醒期与术后早期镇痛效应的影响 　　【摘要】 目的：?^察不同剂量地佐辛对全麻甲状腺手术后患者苏醒期与术后早期镇痛效应的影响。方法：选择择期全麻下行甲状腺切除手术患者120例，按照随机数字表法分为四组，每组30例：D1组静脉予地佐辛0.05 mg/kg，D2组静脉予地佐辛0.1 mg/kg，D3组静脉予地佐辛0.15 mg/kg，C组为对照组静脉予等容积0.9%生理盐水，均于术毕前10 min注药；分别于麻醉前（T0）、术毕前10 min（T1）、予地佐辛后5 min（T2）、10 min（T3）、气管拔出前（T4）、拔管后5 min（T5）、10 min（T6）、20 min（T7）、送出PACU时（T8）记录患者MAP、HR、RR、SpO2值；观察围拔管期MAP、HR变化及不良反应，评估术后12 h内VAS及SAS评分。结果：四组患者一般情况组间比较，差异均无统计学意义（P0.05）；D2、D3组患者T6～T8时与C组比较，MAP、HR显著降低（P0.05）；D1组出现呛咳3例（10%），D2组与D3组患者拨管平稳，C组出现呛咳21例（70%）、出现恶心呕吐6例（20%）；各组患者与对照组比较，术后12 h内VAS评分显著降低，SAS评分术后4 h内显著降低，差异均有统计学意义（P 　　【关键词】 甲状腺手术； 地佐辛； 围拔管期； 术后镇痛 　　Effects of Different Doses of Dezocine on the Recovery Quality and Early Postoperative Analgesic Effect from General Anesthesia Undergoing Thyroidectomy/TANG Zhi-wei，OUYANG Ming-wen，JIANG Li-ping，et al.//Medical Innovation of China，2017，14（05）：065-068 　　【Abstract】 Objective：To investigate the effects of different doses of Dezocine on the recovery quality and early postoperative analgesic effect from general anesthesia undergoing thyroidectomy.Method：A total of 120 patients were scheduled for thyroidectomy.They were randomly divided into four groups，30 cases in each group：group D1 received Dezocine 0.05 mg/kg intravenously，group D2 received 0.1 mg/kg intravenously，group D3 received 0.15 mg/kg intravenously and group C with same volume of normal saline.All patients received the above drug or saline 10 minutes before end of operation.MAP，HR，RR，SpO2，were recorded before beginning anesthesia（T0），10 minutes before end of operation（T1），5 minutes（T2） and 10 （T3） minutes after received the above drug，time of before extubation（T4），5 minutes（T5），10 minutes（T6），20 minutes（T7） after extubation，the end of PACU time（T8），MAP and HR，any side reaction during extubation，visual analogue pain scale（VAS） and SAS scores of two groups were compared.Result：General character without meaningful on statistics among four groups（P0.05）.MAP and HR in group D2 and D3 were lower than those of C group at