定量构效关系The OECD (Q)SAR Application Toolbox.docxVIP

The OECD (Q)SAR Application Toolbox What does the Toolbox do?/document/54/0,3343,en_2649_343791_1_1_1,00.htmlDownload the (Q)SAR Application Toolbox/document/54/0,3343,en_2649_343791_1_1_1,00.htmlGuidance Documents and Training Materials for Using the Toolbox/document/54/0,3343,en_2649_343791_1_1_1,00.htmlAn Overview of Phase 2 development of the Toolbox/document/12/0,3343,en_2649_343791_1_1_1,00.htmlFAQs on the Toolbox?As part of the OECD activities to increase the regulatory acceptance of (Q)SAR methods, the OECD has started the development of a (Q)SAR Application Toolbox as a means of making QSAR technology readily accessible, transparent, and less demanding in terms of infrastructure costs.?The Toolbox is developed?in two phases. The first version emphasises technological proof-of-concept and was released in March 2008.? A first update, version 1.1 was released in December 2008.? The second phase of the project to develop a more comprehensive Toolbox which fully implements the capabilities of the first version was launched in November 2008.?What does the Toolbox do?The Toolbox is a software application intended to be used by governments, chemical industry and other stakeholders in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals.? The Toolbox incorporates information and tools from various sources into a logical workflow.? Crucial to this workflow is?/document/6/0,3343,en_2649_343791_1_1_1,00.htmlgrouping chemicals into chemical categories.?The seminal features of the Toolbox are:1.?Identification of relevant structural characteristics and potential mechanism or mode of action of a target chemical.2.?Identification of other chemicals that have the same structural characteristics and/or mechanism or mode of action.3.?Use of existing experimental data to fill the data gap(s).?Additonal information material has been developed which can be freely used for communication purposes:- Overv