肝硬化患者血清前白蛋白、总胆汁酸及载脂蛋白的检测及其临床意义.docVIP

精品论文 参考文献 肝硬化患者血清前白蛋白、总胆汁酸及载脂蛋白的检测及其临床意义 张巍 陈春光 江卓 刘晓莉 吕萌萌 (河南省传染病医院检验科 450015) 【中图分类号】R575.2【文献标识码】A【文章编号】1672-5085（2012）14-0121-02 【摘要】目的 探讨肝硬化患者血清前白蛋白（PA），总胆汁酸(TBA)，载脂蛋白A1（ApoA1），载脂蛋白B（ApoB）等四项指标对诊断肝硬化的临床应用价值。方法 采用贝克曼全自动生化分析仪检测165例肝硬化患者（肝硬化伴腹腔积液100例，无腹腔积液65例）和100例健康对照组血清中PA、TBA、ApoA1、ApoB的水平，并对检测结果进行统计学分析。结果肝硬化患者血清PA、ApoA1、ApoB水平较对照组明显下降，差异具有统计学意义（P＜0.01）；TBA水平较对照组显著升高（P＜0.01）。肝硬化伴腹腔积液患者PA、ApoA1水平明显低于无胸腔积液患者，差异具有统计学意义（P＜0.01），随着病情不断加重TBA水平升显著增高（P＜0.01）结论 联合检测肝硬化患者血清PA、TBA、ApoA1、ApoB水平，对于肝硬化患者的早期诊断、预后判断，观察病情程度及转归均具有一定的临床参考价值。 【关键词】肝硬化 前白蛋白 总胆汁酸 载脂蛋白A1 载脂蛋白B Clinical Significance of PA、TBA、ApoA1 and ApoB Determination in Patients with Posthepatitic Cirrhosis Zhang Wei,Chen Chun-guang,Jiang zhuo,Liu Xiao-li,Lv Meng-meng (Department of clinical laboratory,Infectious Disease Hospital,Henan province,450015) 【Abstract】 Objective To explore the significance o f serum PA,TBA,ApoA1and ApoB in diagnosis of Posthepatitic Cirrhosis.Method Serum PA,TBA,ApoA1and ApoB in patients with 165 cases liver cirrhosis patients(100 cases with ascites,65 cases with no peritoneal effusion)and 100 healthy volunteers were detected by the BECKMAN automatic biochemical analyzer,and the results are statistically analyzed.Results Serum PA,ApoA1,ApoB levels in patients with cirrhosis decreased significantly compared with the control group, the difference was statistically significant(Plt;0.01);TBA levels increased significantly compared with the control group(Plt;0.01).PA,ApoA1 levels in patients of liver cirrhosis with ascites with were significantly lower than those without pleural effusion patients,the difference was statistically significant(Plt;0.01),TBA levels is continued to increase significantly as the disease aggravation(Plt;0.01).Conciusion Detection of serum PA,TBA,ApoA1 and ApoB levels in patients with liver cirrhosis has certain clinical value for early diagnosis,prognosis,severity of disease and prognosis observation 【Keywords】 Posthepatitic Cirrhosis Prealbumin T