Amino Acid Sequence Comparison of DsrP Protein from….pdfVIP

Send Orders fo r Rep rints to rep rints@ The Op en Structural Biology Journal, 2013, 5, 1-10 1 Open Access Amino Acid Sequence Comparison of DsrP Protein from Proteobacteria to Analyze the Probable Molecular Mechanism of Sulfur Oxidation Process * Semanti Ghosh and Angshuman Bagchi Dep artment of Biochemistry and Biop hy sics, University of Kaly ani, Kaly ani, Nadia- 741235, India Abstract: Sulfur metabolism, the oldest known redox processes mediated by dsr operon, maintain s the environmental sulfur balance. DsrP protein from the dsr operon transports electrons from the environmental sulfur substrates for per- forming the reactions. We therefore, tried to analyze the probable molecular basis of DsrP proteins u sing only the se- quence information. We also tried to predict the effects of the mutation s present in the sequences of DsrP proteins and a phylogenetic relationship between the organisms possessing the operon has been drawn. Our study may therefore shed light in the hitherto unknown biochemical mechanism of the sulfur oxidation process through dsr operon. Keywords: dsr operon, DsrP protein, Domain analysis, Mutation study, Phylogenetic classification, Sequence alignment, Transmembrane domain. 1. INTRODUCTION dsrC, dsrM, dsrK, dsrL, dsrJ, dsrO, dsrP, dsrN , dsrS and dsrR is involve