苯磺酸氨氯地平对大鼠肝微粒体细胞色素P450同工酶的影.docVIP

《苯磺酸氨氯地平对大鼠肝微粒体细胞色素P450同工酶的影响》可行性报告 立项的背景及意义 苯磺酸氨氯地平为一线降压药，可用于治疗各种类型高血压（单独或与其他药物合并使用）和心绞痛，对肾脏有一定的保护作用。[1]EvansWE, RellingMV. Pharmacogenomics:translating functional genomics into rational therapeutics [J].Science, 1999, 286(5439): 487-491. [2]李晓宇,刘皋林.CYP450酶特性及其应用研究进展[J].中国临床药理学与治疗学,2008, 13(8):942–946. [3] 朱大岭,韩维娜,张荣.细胞色素P450酶系在药物代谢中的作用[J].. 医药导报,2004,23（7）：440-443. [4]Park BK.. Cytochrome P450 enzymes in the heart [J].Lancet,2000,355(9208):945. [5] 冷欣夫，邱星辉编著.细胞色素P450酶系的结构、功能与应用前景[M].科学出版社.2001,52-53. [6] 尹海萍，徐建平，杨绍华，等. 维生素E拮抗急性二噁英对小鼠肝脏细胞色素P450酶和抗氧化物酶基因转录的影响[J].动物学报，2008，54(6)：1038-1043. [7] Gonzalez FJ, Kimura S.Study of P450 function using gene knockout and transgenic mice[J]. Arch Biochem Biophys,2003,409(1):153-158 [8] Wang XJ, Chamberlain M, Vassieva O et al.Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice[J].Biochem J,2005,388(Pt3):857-867 [9] Richardson TA, Sherman M, Antonovic L et al.Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice[J].Drug Metab Dispos,2006,34(3):354-360 [10] 李芹,王睿. 细胞色素P4502D6基因多态性和药物相互作用[J].中国临床药理学与治疗学,2006,11(4):369–374. [11] 卢琴,陈西敬,王广基.药物基因组学在药动学研究中的应用[J]..中国药科大学报,2005,36 (5):473–476. [12]Yuan R,Madani S,Wei X X, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions [J]. Drug Metab Dispos, 2002, 30(12):1311-1319. [13]Faucette S R, Hawke R L,Lecluyse E L, et al. Validation of bup ropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity [J].Drug Metab Dispo,2000,28(10):1222-1230. [14]郭喻,汪晖.人细胞色素P450同工酶探针底物特异性的研究进展[J].中国药理学通报, 2007,23(7):851-854. [15]扈金萍,陈晖,李燕.S(+)盐酸氯胺酮对大鼠肝微粒体细胞色素P450同工酶的影响[J].中国药学杂志,2008,43（12）:906-909. [16]Wang Ai-hong,Xia Zhao-lin.The assay of CYP2E1 activity in biological system [J].Chinese J Ind Med,2003,16(6):354. [17]金科涛,石苏英,沈建幸,等.高效液相色谱法测定人肝细胞色素P4