甲氨蝶呤联合米非司酮保守治疗异位妊娠疗效分析.docVIP

精品论文 参考文献 甲氨蝶呤联合米非司酮保守治疗异位妊娠疗效分析 曹爽(大连市金州区第一人民医院妇产科 116100) 　　 　　【摘要】目的 探讨甲氨蝶呤联合米非司酮保守治疗异位妊娠的临床疗效。方法 将我院近两年180例异位妊娠患者分为两组，每组90例，对照组单用甲氨蝶呤肌注治疗，观察组用甲氨蝶呤联合米非司酮治疗，回顾性分析两种保守治疗方法 的疗效。结果 两组在血清beta;-HCG降至正常所需天数、包块减小所需天数、住院天数上比较，观察组明显优于对照组，差异有显著性，Plt;0.05。结论 甲氨蝶呤联合米非司酮保守治疗异位妊娠疗效确切，安全可靠，可适当放宽异位妊娠保守治疗指征。 　　【关键词】异位妊娠 甲氨蝶呤 米非司酮 保守治疗 　　【中图分类号】R969.4 【文献标识码】A 【文章编号】1672-5085（2013）49-0046-02 　　Efficacy Analysis of Influences of Methotrexate Joint Mifeprestone on Ectopic Pregnancy 　　【Abstract】 Objective: To explore the efficacy of methotrexate combined with mifeprestone in the treatment of ectopic pregnancy. Method: 180 cases of patients diagnosed as ectopic pregnancy in our hospital in recent two years were divided into two groups of 90 cases. The patients in control groups were injected with methotrexate alone. The patients in experimental group were injected with methotrexate combined with mifeprestone. We analyse the efficacy of the two conservative treatment through a retrospective cohort. Result: We analyse the serum beta;-HCG、the package block size and the hospitalized time. There were significantly difference in the normal serum beta;-HCG time of restoration, hospital time and lump size compared treat group with control group (Plt; 0.05) . Conclusion: Methotrexate combined with mifeprestone in the conservative treatment of ectopic pregnancy was effective and safe. It was safe to appropriately broaden the indication of conservative treatment of ectopic pregnancy 　　【key words】 ectopic pregnancy methotrexate mifepristone conservative treatment 　　异位妊娠是受精卵在子宫体腔以外部位着床，是妇产科常见的急腹症之一。近年来随着医疗诊断技术以及人们看病意识的提高，异位妊娠的检出率明显上升，减少了休克的发生。同时由于米非司酮及甲氨蝶呤药物的应用，使得异位妊娠保守治疗成功率大大提升。本研究就我院180例行保守治疗的异位妊娠患者的资料进行了回顾性分析。 　　1 资料与方法 　　1.1 一般资料 收集2011年6月—2013年6月我院妇科收治的异位妊娠患者180例，血beta;-HCGle;3000mIU/ml，经阴道超声提示包块直径le;5cm，排除宫角妊娠、宫颈妊娠、切口妊娠等特殊类型的异位妊娠。所有患者生命体征平稳，无腹痛或仅有腹部隐痛，有或无腹腔内出血（经阴道超声提示盆腔积液量lt;5cm），血常规及肝肾功均正常。年龄22-38岁，孕周6-9周。所有患者无米非司酮及甲氨