氯氮平合并利培酮治疗难治性精神分裂症临床分析.docVIP

精品论文 参考文献 氯氮平合并利培酮治疗难治性精神分裂症临床分析 山东省济宁市精神病防治院 山东济宁 272051 摘要：目的：评价氯氮平联合利培酮治疗难治性精神分裂症临床疗效、安全性。方法：对85例难治性精神分裂症患者给予氯氮平联合利培酮治疗，对比简明精神病评定量表（BPRS）、大体功能量表（GAS）、社会功能缺陷筛查量表（SDSS）变化，记录不良反应发生情况。结果：临床痊愈33例，显效31例，有效18例，无效3例；第16周后BPRS、SDSS积分低于第4周，第四周低于第1周，第1周低于治疗前，第16周后GAS积分高于第4周，第四周高于第1周，第1周高于治疗前，差异具有统计学意义（P＜0.05）；不良反应发生率100%，主要不良反应为心肝肾功能异常、体重增加、嗜睡等。结论：氯氮平联合利培酮治疗难治性精神分裂症疗效较好，多数患者数周内精神症状可获得显著改善，大体功能、社会功能初步恢复，但不良反应发生率较高，应酌情用药，采用序贯给药等方法控制药量，积极采取家庭干预等其它方法巩固疗效，治疗期间定期开展不良反应监测。 关键词：精神分裂症；氯氮平；利培酮；疗效观察 [Abstract]Objective：To evaluate the clozapine and risperidone in the treatment of refractory schizophrenia clinical efficacy，safety.Methods：85 cases of intractable schizophrenia patients given clozapine combined with risperidone in the treatment of mental illness，contrast scale（BPRS），generally function scale（GAS），social disability screening schedule（SDSS）changes，record the occurrence of adverse reactions.Results：the clinical cure 33 cases，markedly effective in 31 cases，effective 18 cases，invalid 3 cases；sixteenth weeks afterBPRS，SDS integral in less than fourth weeks，4 weeks in less than first weeks，first weeks was lower than that before treatment，sixteenth weeks after the GAS integral is higher than that of the fourth week，the fourth week more than firstweeks，first weeks was higher than that before treatment，with statistically significant differences（P lt; 0.05）；the incidence of adverse reaction of 100%，the main adverse reactions were liver and kidney dysfunction，weight gain，somnolence etc..Conclusion：Clozapine and risperidone in the treatment ofrefractory schizophrenia curative effect is better，the majority of patients within a few weeks of psychiatric symptoms can be significantly improved，the initialrecovery generally function，social function，but has a high incidence of adverse reaction，as appropriate，medication，using sequential administration methods such as charge control，actively adopt other methods such as family interventionto consolidate the curative effect，adverse reaction dur