2015-Mol Cell Proteomics-致病性结核分枝杆菌的琥珀酰化修饰参与新陈代谢的调节.pdfVIP

Research © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. This paper is available on line at Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in □ Pathogenic Mycobacterium tuberculosis* S Mingkun Yang‡, Yan Wang‡, Ying Chen‡, Zhongyi Cheng§, Jing Gu¶, Jiaoyu Deng¶, Lijun Bi, Chuangbin Chen**, Ran Mo‡, Xude Wang¶, and Feng Ge‡‡‡ Mycobacterium tuberculosis (Mtb), the causative agent of functional analyses of lysine succinylation and facilitate human tuberculosis, remains one of the most prevalent the dissection of metabolic networks in this life-threat- human pathogens and a major cause of mortality world- ening pathogen. Molecular Cellular Proteomics 14: wide. Metabolic network is a central mediator and defin- 10.1074/mcp.M114.045922, 796–811, 2015. ing feature of the pathogenicity of Mtb. Increasing evi- dence suggests that lysine succinylation dynamically regulates enzymes in carbon metabolism in both bacteria 1 Post-translational modifications (PTMs) are complex and and human cells; however, its extent and function in Mtb fundamental mechanisms modulating diverse protein proper- remain unexplored. Here, we performed a global succi-