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Article /JAFC Comparative Study of Microbial-Derived Phenolic Metabolites in Human Feces after Intake of Gin, Red Wine, and Dealcoholized Red Wine Ana Jimenez-Giron,́ ́ † María Isabel Queipo-Ortuno,̃ § Maria Boto-Ordonez,́ ̃ #,⊥ Irene Munoz-Gonzalez,̃ ́ † Fernando Sanchez-Patan,́ ́ † Maria Monagas,† Pedro J. Martín-Alvarez,́ † Mora Murri,# Francisco J. Tinahones,§ Cristina Andres-Lacueva,́ # Begona Bartolome,*̃ ́ ,† and M.Victoria Moreno-Arribas† †Instituto de Investigacion en Ciencias de la Alimentacion (CIAL), CSIC-UAM, c/Nicolas Cabrera 9, 28049 Madrid, Spaiń ́ ́ §CIBER de Fisiopatología de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain, and Servició Endocrinologıa y Nutricion del Hospital Universitario Virgen de la Victoria, Malaga, Spaiń ́ ́ #Department of Nutrition and Food Science, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain ⊥Fundacio Clınic per a la Recerca Biomedica, Barcelona, Spaiń ́ ́ S *Supporting Information ABSTRACT: The analysis of microbial phenolic metabolites in fecal samples from in vivo studies is crucial to understanding the potential modulatory effects derived from polyphenol consumption and its overall health effects, particularly at the gut level. In this study, the composition of microbial phenolic metabolites in human feces collected after regular consumption of either red wine, dealcoholized red wine, or gin was analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change in the content of eight phenolic acids, which are prob
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