Ochratoxin A and T 2 Toxin Induce Clonogenicity and Cell Migration in Human Colon Carcinoma and Fetal Lung Fibroblast Cell Lines英文电子书.pdfVIP

J BIOCHEM MOLECULAR TOXICOLOGY Volume 30, Number 3, 2016 Ochratoxin A and T-2 Toxin Induce Clonogenicity and Cell Migration in Human Colon Carcinoma and Fetal Lung Fibroblast Cell Lines Haila Abassi,1 Imen Ayed-Boussema,1 Sarah Shirley,2 Salwa Abid,1 and Hassen Bacha1 1 ´ ´ Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculte de Medecine Dentaire 5019, Monastir, Tunisia; E-mail: hassen.bacha@fmdm.rnu.tn 2 ´ INSERM, U866, Universite de Bourgogne, Dijon F-21000, France Received 12 June 2015; revised 1 September 2015; accepted 10 September 2015 ABSTRACT: T-2 toxin and Ochratoxin A (OTA) are a large variety of grains and feedstuffs worldwide toxic secondary metabolites produced by various fungi, [1–3]. The classification of mycotoxins is based upon and together they contaminate feedstuffs worldwide. their frequency of occurrence and/or the severity of T-2 toxin and OTA may exert carcinogenic action in the disease induced, e.g., cancer [4]. Thus, T-2 toxin rodent. Despite the various in vivo experiments, car- and Ochratoxin A (OTA) are considered among the cinogenicity of these two mycotoxins has not yet been most commonly encountered mycotoxins in the world, proven for human. In this current study, we proposed to investigate, in Human colon carcinoma cells and which cause severa