Staphylococcus aureus superantigens and airway disease英文电子书.pdf

Staphylococcus aureus Superantigens and Airway Disease Claus Bachert, MD, PhD*, Philippe Gevaert, MD, and Paul van Cauwenberge, MD, PhD *Address gastrointestinal tract, and the blood system [1]. Skin infec- Department of Oto-Rhino-Laryngology, Ghent University Hospital, tions, lung abscesses, pneumonia, osteomyelitis, food poi- De Pintelaan 185, B-9000 Ghent, Belgium. soning, fever, scalded skin syndrome, and toxic shock Email: claus.bachert@rug.ac.be syndrome are among the most common conditions. Current Allergy and Asthma Reports 2002, 2:252–258 Although the pathogenicity of S. aureus is closely correlated Current Science Inc. ISSN 1529-7322 Copyright © 2002 by Current Science Inc. with the production of coagulase enzymes, and many conditions result as a consequence of invasion by the bacterium, these organisms also contain a number of Twenty-five percent of the population are permanent cellular antigens and produce a variety of toxins with carriers of Staphylococcus aureus, possibly producing a superantigenic properties [2,3]. Recent studies of these variety of toxins with superantigenic properties. staphylococcal superantigens have demonstrated that they Staphylococcal superantigens are a group of high-