Mitochondrial DNA nucleoids determine mitochondrial genetics and dysfunction英文电子书.pdf

The International Journal of Biochemistry Cell Biology 41 (2009) 1899–1906 Contents lists available at ScienceDirect The International Journal of Biochemistry Cell Biology j o u rn al h omepage: w w w. elsev /locate/biocel Review Mitochondrial DNA nucleoids determine mitochondrial genetics and dysfunction Robert W. Gilkerson Department of Neurology, College of Physicians Surgeons, Columbia University, Russ Berrie Pavilion 307, 1150 St. Nicholas Ave., New York, NY 10032, United States a r t i c l e i n f o a b s t r a c t Article history: Mitochondrial DNA plays a crucial role in cellular homeostasis; however, the molecular mechanisms Available online 9 April 2009 underlying mitochondrial DNA inheritance and propagation are only beginning to be understood. To ensure the distribution and propagation of the mitochondrial genome, mitochondrial DNA is packaged Keywords: into macromolecular assemblies called nucleoids, composed of one or more copies of mitochondrial Mitochondria DNA and associated proteins. We review current research on the mitochondrial nucleoid, including Mitochondrial DNA nucleoid-associated proteins, nucleoid dynamics within the cell, potential mechanisms to ensure proper Nucleoids