Hormesis Protecting neurons against cellular stress in Parkinson disease英文电子书.pdf

VIEWS AND COMMENTARIES Autophagy 8:6, 997–1001; June 2012; G 2012 Landes Bioscience Hormesis Protecting neurons against cellular stress in Parkinson disease Soledad Matus,1,2,3,* Karen Castillo1,2 and Claudio Hetz1,2,3,4,* 1Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; 2Center for Molecular Studies of the Cell; Institute of Biomedical Sciences; University of Chile; Santiago, Chile; 3Neurounion Biomedical Foundation; Santiago, Chile; 4Department of Immunology and Infectious diseases; Harvard School of Public Health; Boston, MA USA Protein folding stress is a salient many neurodegenerative diseases includ- feature of the most frequent neuro- ing amyotrophic lateral sclerosis (ALS), degenerative diseases. Although the accu- Alzheimer disease, Parkinson disease mulation of abnormally folded proteins (PD), and Huntington disease (HD). is a well-characterized event underlying Perturbation in protein homeostasis is the pathology, the way cells respond to currently proposed as a key factor under- © 2012 Landes Bioscience. this phenomenon is not well understood. lying the pathological effects of most of Signs of endoplasmic reticulum (ER) the well-characterized brain disease-linked