The role of regulatory t lymphocytes in asthma pathogenesis英文电子书.pdf

The Role of Regulatory T Lymphocytes in Asthma Pathogenesis Douglas S. Robinson, MD, FRCP Address ment of autoimmune pathology that could be prevented Leukocyte Biology Section, Biomedical Sciences Division and Allergy by re-introduction of these cells from other mice. and Clinical Immunology, National Heart and Lung Institute, Faculty Such CD4+ + CD25 regulatory T cells were active in many of Medicine, Imperial College London, Sir Alexander Fleming Building, disease models, and could reverse established inflam- Exhibition Road, London SW7 2AZ, England. E-mail: d.s.robinson@imperial.ac.uk matory disease models, such as colitis [7]. These cells were Current Allergy and Asthma Reports 2005, 5: 136–141 shown to arise by high affinity selection in the thymus, Current Science Inc. ISSN 1529-7322 and are thought to form a “naturally occurring” regulatory Copyright © 2005 by Current Science Inc. population that acts in tolerance or nonreactivity of the immune system against itself [8•,9]. Thornton and Shevach [10] showed that mouse CD4+ + Several subtypes of regulatory or suppressive T cells CD25 T cells do have been described that can prevent activation of effec- not proliferate to polyclonal or antigenic stimulation in tor T cells in vitro and in vivo in animal models. Recent culture, and, furthermore, they suppress