Hepatocellular carcinoma and the ubiquitin proteasome system英文电子书.pdf

Biochimica et Biophysica Acta 1782 (2008) 775–784 Contents lists available at ScienceDirect Biochimica et Biophysica Acta j ournal home page: www. elsevier. com/ locate/ bba di s Review Hepatocellular carcinoma and the ubiquitin–proteasome system Simon P. Dawson School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK a r t i c l e i n f o a b s t r a c t Article history: Hepatocellular carcinoma is one of the largest causes of cancer-related deaths worldwide for which there are Received 14 July 2008 very limited treatment options that are currently effective. The ubiquitin–proteasome system has rapidly Received in revised form 8 August 2008 become acknowledged as both critical for normal cellular function and a frequent target of de-regulation Accepted 11 August 2008 leading to disease. This review appraises the evidence linking the ubiquitin–proteasome system with this Available online 20 August 2008 devastatingly intractable cancer and asks whether it may prove to be fertile ground for the development of Keywords: novel therapeutic interventions against hepatocellular carcinoma. Hepatocellular carcinoma © 2008 Elsevier B.V. All rights reserved. Ubiquitin Cancer Proteasome Inflammation 1. Hepatocellular carcinoma: the problem