我院2008—2009年度氨基糖苷类药物对大肠埃希菌耐药现状分析.docVIP

精品论文 参考文献 我院2008—2009年度氨基糖苷类药物对大肠埃希菌耐药现状分析 廖础欣 温冬梅（广东省中山市人民医院药学部 广东中山 528403） 【中图分类号】R978.1+2 【文献标识码】A 【文章编号】2 0 9 5 - 1 7 5 2 （ 2 0 1 1 ） 2 3 - 0 1 4 3 - 0 3 【摘要】目的 了解医院常见临床分离大肠埃希菌的分布情况及耐药现状,为临床医生合理使用抗菌药物治疗感染性疾病提供依据。方法 收集2008年1月1号至2009年12月31号临床各科送检标本，采用美国德灵MicroScanWalkAway240全自动微生物分析仪同时进行菌株鉴定与药敏测定，分析大肠埃希菌中ESBL s阳性菌和阴性菌对抗菌药物的耐药情况。结果 共分离出大肠埃希菌965株，2008年度对庆大霉素、卡那霉素、链霉素、妥布霉素、奈替米星、阿米卡星的耐药率分别为：65.58％、60.15％、52.26％、40.94％、16.98％，11.21 %。2009年度庆大霉素、卡那霉素、链霉素、妥布霉素、奈替米星、阿米卡星的耐药率分别为：68.08％、62.75％、56.96％、40．64％、20.68％，14.31 %。临床分离的ESBLs大肠埃希菌对庆大霉素耐药率最高，对阿米卡星敏感性最高。结论 各种药物耐药菌总数09年度比08年度有上升。大肠埃希菌对不同氨基糖苷类抗菌药物的耐药程度不同，临床应加强对细菌感染性疾病的耐药性监测,并根据药敏试验结果合理选择抗菌药，以指导临床用药。 【关键词】大肠埃希菌 氨基耱苷类 耐药性 超广谱beta;内酰胺酶 Analysis of the Antibiotic Resistance of Escherichia Coli to Aminoglycoside Antibiotics in from 2008 to 2009Liao chuxin wen dongmei(Zhongshan Peoples Hospital Department of Pharmacy, Guangdong Province Zhongshan City, 528403) 【Abstract】Objective To investigate the distribution of Escherichia Coli and antimicrobial resistance guide drug treatment and reasonable application of antibiotics in clinic. Methods The strain identification and drug sensitivity test was conducted by MicroScan WalkAway240 Full-automatic testing system of microbiology. Results　Among 965 isolates obtained，the resistance to Gentamicin, kanamycin, streptomycin, Tobramycin, netilmicin, amikacin, each was 65.58%,60.15%, 52.26%, 40.94%, 16.98%, 11.21% in 2008; but 68.08%,62.75%,56.96%,40.64%,20.68%,14.31%in 2009. ESBLs-producing Escherichia coli resistant to gentamicin highest rate, the maximum sensitivity to amikacin. Conclusio Drug Resistant Strain for aminoglycosides had the tendency of increase. Escherichia coli to different aminoglycoside antibiotic resistance in varying degrees.Clinical disease resistance surveillance should be strengthened，and a reasonable choice based on susceptibility test results antibacterial drugs to guide the clinical use of drugs. 【Key words】Escherichiacoli Ecoli aminoglycosides