有机小分子催化的不对称直接Aldol反应研究新进展-河北工业科技.PDFVIP

22 2 河 北 工 业 科 技 V ol . 22, No . 2 2005 3 H ebei J our nal of Indu str ial Science and T echno log y M ar . 2005 2005) 020 10608 A ldol 1 2 3 4 , , , ( 1. 石家庄市铜铝制品厂, 河北石家庄 050011; 2. 河北科技大学研究生学院, 河北石家庄 0500 18; 3. 河北科技大学化学与制药工程学院, 河北石家庄 0500 18; 4 河北科技大学后勤管理 处, 河北石家庄 050018) 对 些年来L 脯氨酸( LP roline) 等6 类有机小分子催化剂催化不对称直接A ldol 反应的 特点实用范围及结果作了详细介绍, 认为该领域具有广阔的发展前景 有机小分子催化剂; 不对称催化; 直接不对称A ldol 反应; L脯氨酸( LP roline) O 643 . 3 A Recent progress in t he small organic m olecule cat aly zed direct asy m m etr ic A ldol react ion 1 2 3 4 ZH A N G Baohu a , CH EN Xiangmin , SH I L anx iang , Y A N G H u ilong ( 1. Shijiazhu ang Co pper and A lum inium Pr oduct s Facto ry , Shijiazhu ang H ebei 050011, China; 2. Colleg e of P ostg radu ates, He bei U niv ersity of Science and T echnolog y, Shijiazhuang H ebei 0500 18, China; 3 . Co llege o f Chem ica l and Ph arm aceutical Eng i neering , H ebei U niver sity of Science and T echnolo gy , Shijiazhu ang H ebei 0500 18, China; 4 . A dm inistrative O ff ice o f R ea r Ser v ice, Hebei U niv ersity of Science and T echnolog y, Shijiazhuang H ebei 0500 18, China) Abstract: T he six kinds o f sm all org anic molecule catalyzed dir ect asy mm etric aldol reactio n in recent year s are r eview ed, in cluding their reaction ch ar act ers, the r ang e o f application and r esult s. Lpr oline as a ty pical direct asy mm etric sm all o rg anic molecule catalyst promo tes aldol reaction s . T he direct asy mm etric aldo l reactio ns cataly zed by L - pro line and it s analog s ar e o f theo retical signif icance and potenti