炎症收束因子-J-Stage.PDFVIP

( ) ～ ( ) 156156 Jpn. J. Clin. Immunol., 36 3 156 161 2013 2013 The Japan Society for Clinical Immunology 総 説 炎症収束因子―自然免疫から獲得免疫への橋梁― 遠藤平仁 Resolving factors of in‰ammation―a bridge between Innate immunity and Adaptive immunity Hirahito ENDO Division of Rheumatology, Department of Internal Medicine, Toho University ( ) Accepted April 4, 2013 summary Acute in‰ammation, a physiologic response to protect cells from microbial infection and other stimuli, is auto- matically terminated by endogenous anti-in‰ammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of in‰ammation is failed, in‰ammation persists and can progress to a chronic in‰amma- tion such as rheumatoid arthritis, interstitial pneumonitis. To prevent chronic in‰ammation, understanding the process that resolves in‰ammation is essential. Resolution of in‰ammation is an active coordinated process regulated by dis- tinct anti-in‰ammatory and pro-resolving endogenous lipid mediators, such as lipoxins/ALX, chemerin/chemR23. In resolution of in‰ammation these resolving factors contribute a bridge between innate and adaptive immunity. Key words―resolution; lipoxin; chemerin; rheumatoid arthritis; interstitial pneumonitis 抄 録 体外からの細菌感染や外傷などによる急性炎症は早期に血管浸過性亢進と好中球を中心とする炎症細胞の浸潤が 起こる．炎症により破壊された組織は正常の組織に修復される．急性炎症で好中球の浸潤がおこりその後マクロフ ァージ，リンパ球の浸潤と異物の貪食除去の炎症収束，組織修復と生体反応は展開する．急性炎症は自己制御され 収束（Resolution）し組織修復する．この転換期に脂質メデイエータのLipoxin やResolvin や抗炎症サイトカイン IL-10 やアデイポカインChemerin など多くの因子が作用する．Lipoxin はリポキシゲナーゼ（LOX）により合成 される．急性炎症の早期は リポキシゲナーゼ（