亚低温治疗重型颅脑损伤患者临床疗效观察及其安全性评价.docVIP

亚低温治疗重型颅脑损伤患者临床疗效分析及对患者血清GFAP、UCH-L1、NSE、CRP水平的影响 摘要 目的：探讨亚低温治疗重型颅脑损伤患者临床疗效分析及对患者血清GFAP、UCH-L1、NSE、CRP水平的影响。方法：106例重型颅脑损伤患者根据随机分组法分为治疗组（n=53）和对照组（n=53）。对照组给予常规治疗，治疗组在对照组基础上结合亚低温治疗。对比分析两组入院时、治疗后1d和治疗后5d颅内压、血糖、血清GFAP、UCH-L1、NSE、CRP指标变化以及治疗6个月后预后情况。结果：两组颅内压第1d、第5d颅内压较入院时明显降低（P0.05）；治疗组颅内压治疗后1d、5d颅内压明低于对照组（P0.05）；两组第1d、第5d血糖水平显著低于入院时（P0.05）；治疗组治疗后1d、5d血糖水平显著低于同期对照组（P0.05）；两组血清GFAP、UCH-L1水平治疗后1d、5d较入院时显著降低（P0.05）；治疗组血清GFAP、UCH-L1水平治疗后1d、5d显著低于对照组（P0.05）；两组NSE、CRP治疗前变化比较无统计学差异（P0.05）；治疗组NSE、CRP治疗后1d和5d明显低于同期对照组（P0.05）；治疗组良好率显著高于对照组（P0.05），死亡率显著低于对照组（P0.05）；而两组中残、重残及植物状态对比无统计学差异（P0.05）。结论：亚低温治疗重型颅脑损伤患者临床疗效显著，降低血清GFAP、UCH-L1、NSE、CRP水平，改善患者预后，值得进一步推广应用。 关键词：亚低温；重型颅脑伤；疗效；GFAP；UCH-L1；NSE；CRP Hypothermia treatment of clinical efficacy in patients with severe brain damage in patients with serum indicators of GFAP,UCH-L1, NSE；CRPlevels Abstract Objective: To investigate the clinical effect of mild hypothermia on patients with severe craniocerebral injury and the effect of serum GFAP, NSE, UCH-L1 and CRP levels in patients with severe craniocerebral injury. Methods: 106 cases of severe traumatic brain injury patients according to randomized divided into treatment group (n=53) and control group (n=53). The control group received conventional treatment group combined with hypothermia were based on. Comparative analysis of two hospitalized, 5d intracranial pressure, blood glucose, serum GFAP, UCH-L1, NSE, CRP levels, cerebrovascular Indexes 1d after treatment and therapy and 6 months post-treatment prognosis. Results: There intracranial pressure on 1d, 5d significantly lower intracranial pressure compared with the first admission (P0.05); intracranial pressure therapy treatment group 1d, 5d Ming intracranial pressure than the control group (P0.05); two pairs of 1d, paragraph 5d significantly lower blood glucose levels at admission (P0.05); 1d, 5d glucose levels in the treatment group was significantly lower than that in the control group (P0.05); levels of serum GFAP, UCH-L1 levels