生物反应器课件 Renowed customer application Applikon’s BioSep system.pptVIP

Renowned user application Applikon’s BioSep system Content Overview Principle of operation BioSep Publication results Customers in Europe Novartis, Cell, cGMP Dutch Vaccine Institute, Cell, cGMP HPA, UK, Cell, cGMP Glaxo Smith Kline, Cell, cGMP Boehringer Ingelheim, Cell, cGMP Solvay Pharmaceuticals, Cell, cGMP Astra Zeneca Bayer, Cell, cGMP Eli Lilly Pfizer Fraunhofer Institute, cGMP Diosynth, Cell, cGMP Pharmacia Avantis Pasteur, Cell, cGMP Merial, Cell, cGMP Alba Biosciences, Cell, cGMP Sanofi Aventis Sandoz Vivalis, Cell, cGMP Avecia, Cell, cGMP L.F.B., Cell, cGMP Cobra Biologicals, Cell, cGMP Centocor, Cell, cGMP Serbio, Cell, cGMP Natl. BioManuf. Centre, Cell, cGMP OctoPlus U.C.B. Celltech, Cell, cGMP Cancer Research, Cell, cGMP Synco BioPartners, Cell, cGMP Customers in USA Bayer, Cell, cGMP Genentech, Cell, cGMP Bristol Myers Squib (BMS) Zymogenetics, Cell, cGMP Wyeth Pharmaceuticals BioMarine, Cell, cGMP Invitrogen Amgen, Cell, cGMP Biogen IDEC, Cell, cGMP Abbott Glaxo Smith Kline (GSK), Cell, cGMP Merck, Cell, cGMP Cubist, Cgmp Sigma Aldrich, Cell, cGMP Medimmune, Cell, cGMP Imclone, Cell, cGMP Cambrex, Cell, cGMP Cook Phamica. Overview Many companies work with Applikon Micro scale up to Pilot/Production scale BioSep is unique product for perfusion Renowed user application BioSep integration Principle of operation High movement / Low pressure plane Low movement / High pressure plane Cells accumulate in low pressure planes High movement / Low pressure plane Acoustic standing wave Clarified harvest Concentrated cell suspension Cell “banding” Cell sedimentation Detail cell band BioSep: Economical Impact - Perfusion vs. Batch Viable cell concentration: Factor 10-20 Antibody conc. in harvest: Factor 2-5 Antibody production /reactor volume/day: Factor 10-100 = smaller reactor Scalable 1L – 1000L cGMP BioSep 1000 L BioSep chamber 1000L Scalable 1L – 1000L cGMP BioSep 10L Scalable 1L – 1000L cGMP BioSep 50L