er、pr、ki-67、vegf组织表达与新辅助化疗治疗乳腺癌的疗效相关性分析.docVIP

精品论文 参考文献 ER、PR、Ki-67、VEGF组织表达与新辅助化疗治疗乳腺癌的疗效相关性分析 河北省第七人民医院，河北 保定 073000 基金项目：保定市科技支撑计划（15ZF078） 【摘要】目的：分析ER、PR、Ki-67、VEGF组织表达与新辅助化疗治疗乳腺癌的疗效相关性。方法：收集2010年2月至2015年12月来我院就诊的乳腺癌患者120例，均给予新辅助化疗治疗。将有效患者93例作为有效组，无效患者27例作为无效组。观察两组患者ER、PR、Ki-67、VEGF组织表达，探讨其水平变化与治疗效果的相关性。结果：无效组患者ER、PR、Ki-67、VEGF阳性表达率明显高于有效组，差异具有统计学意义（P＜0.05）。ER、PR、Ki-67、VEGF组织表达与治疗效果均呈负相关（-1le;r＜0），且具有统计学意义(P＜0.05)。结论：ER、PR、Ki-67、VEGF组织表达与治疗效果存在相关性并为负相关，上述表达水平呈阴性，患者治疗效果好。 【关键词】乳腺癌；新辅助化疗；ER；PR；Ki-67；VEGF 【中图分类号】R467.1【文献标识码】A【文章编号】1001-5213(2016)09-0010-02 【Abstract】Object: Analyze the relationship between the expression of ER, PR, VEGF, Ki-67 and neoadjuvant chemotherapy for breast cancer. Method: Collected 120 cases of breast cancer patients accepting treatment in our hospital from February 2010 to December 2015. All were treated by neoadjuvant chemotherapy. Effective patients were 93 cases as effective group, 27 cases of invalid patients as invalid group. The expression of ER, Ki-67, PR and VEGF in the two groups were observed, and the correlation between the level of the patients and the treatment effect was discussed. Result: The positive expression rates of VEGF, PR, Ki-67 and ER in the invalid group were significantly higher than those in the effective group. The difference was statistically significant(P＜0.05).The treatment effect were negatively correlated with the positive expression ER, PR, Ki-67 and VEGF.(-1le;R＜0). The difference was statistically significant (P＜0.05). Conclusion: The treatment effect were negatively correlated with the positive expression ER, PR, Ki-67 and VEGF. The above expression level was negative, and the effect of treatment was good. 【Key word】breast cancer；neoadjuvant chemotherapy；ER；PR；Ki-67；VEGF 乳腺癌是女性最常见的恶性肿瘤疾病，目前在女性人群中发病率高居第一位，严重威胁女性的健康安全[1]。虽然随着乳腺癌治疗研究的深入，以手术治疗及新型放化疗为代表的治疗方法陆续问世并应用于临床，新辅助化疗从20世纪70年代开始应用于乳腺癌的治疗当中。它是一种非侵入性的治疗方法，与普通化疗相比，具有更高的安全性和有效性[2]。本研究通过对乳腺癌患者组织标本进行雌激素受体（estrogen receptor，ER）、孕激素受体（progesterone receptor，PR）、核蛋白Ki-67以及血管内皮生长因子（vascular endo