Release kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticlesRelease kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticles.pdfVIP

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Release kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticlesRelease kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticles.pdf

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Release kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticlesRelease kinetics of drugs from pluronic F127、poly(lactic acid) nanoparticles

Journal of Controlled Release 103 (2005) 73–82 /locate/jconrel Release kinetics of hydrophobic and hydrophilic model drugs from pluronic F127/poly(lactic acid) nanoparticles a a,* b X.Y. Xiong , K.C. Tam , L.H. Gan aSchool of Mechanical and Production Engineering, Nanyang Technological University 639798, Singapore bNatural Sciences, National Institute of Education 637616, Singapore Received 3 June 2004; accepted 16 November 2004 Available online 20 December 2004 Abstract Poly(lactic acid) (PLA) was successfully grafted to both ends of Pluronic F127 block copolymers (PEO–PPO–PEO) to obtain amphiphilic PLA–F127–PLA block copolymers. The block composition and structure of PLA–F127–PLA block copolymers were studied by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimetric (DSC) and wide angle X-ray diffraction (WXRD) techniques. Data from DSC and WXRD measurements indicated that Tg and Tm of PLA blocks in PLA–F127–PLA block polymers are lower than those of PLA homopolymer. Furthermore, Tm and crystallinity of PLA blocks decrease with decreasing PLA block length in PLA–F127–PLA block copolymers. The release behaviors of both hydrophobic 9-(methylaminomethyl)anthracene (MAMA) and hydrophilic procaine hydrochloride (PrHy) model drugs from PLA–F127–PLA nanoparticles with vesicular structure in PBS solution at 37 8C were examined by UV spectroscopy. The release kinetics