糖代谢受损论文：冠心病合并糖代谢异常患者脂蛋白（a）与冠脉病变相关性分析.docVIP

糖代谢受损论文：冠心病合并糖代谢异常患者脂蛋白（a）与冠脉病变相关性分析 【中文摘要】研究冠心病合并糖代谢异常患者脂蛋白（a）与冠脉病变的关系。方法：选择2010年5月--2011年12月在我院心内科住院并经冠状动脉造影证实的470例冠心病患者，详细询问性别、年龄、高血压病史、糖尿病史、吸烟史、所有入选患者入院次日晨起空腹抽取静脉血,测定空腹血糖(FPG)及餐后2h血糖(2hPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)水平。冠脉造影结果由心内科有经验的2名医师判定，按狭窄（≥50%）累及左主干、左前降支、回旋支或右冠脉的支数分为1支、2支、3支病变组,并对冠状动脉的狭窄程度作出定量评价。按照空腹血糖水平将所有入选患者分为四组，各组之间进行冠心病危险因素、以及脂蛋白a和冠脉病变程度相关性的对比，采用SPSS11.5统计软件包进行统计分析，计量资料数据以xｓ表示，并行t检验，设P0.05有统计学意义，计数资料采用χ2检验。结果：随着空腹血糖浓度的逐渐升高，LP(a)、单支病变、3支病变以及累及回旋支发生率逐渐升高，与NGT组相比差异有统计学意义，P0.05；其余三组与NGT组相比, LP(a)与冠脉病变程度的相关性均高于NGT组。结论：冠心病合并糖代谢异常患者累及冠脉的支数以及LP (a)的浓度均高于NGT组；冠心病合并糖代谢异常患者LP(a)与冠脉病变程度的相关性均高于NGT组；及早发现、及时降低冠心病合并糖代谢异常患者脂蛋白（a）水平，可以在一定程度上延缓冠脉病变的发生及发展。 【英文摘要】: To study coronary heart disease and sugar metabolism in patients with abnormallipoprotein (a) with coronary artery disease.Methods: Coronary angiography was Performed for 470 Patients during May 2010 to December2011 in the hospital of Cardiology and confirmed with coronary heart disease patients, and askedin detail about the sex, age, history of hypertension, history of diabetes, smoking history. Fastingplasma glucose (FPG) and 2h postprandial plasma glucose (2hPG), total cholesterol (TC),triglycerides (TG), high-density lipoprotein cholesterol (HDL-C)low-density lipoproteincholesterol (LDL-C), lipoprotein (a) [Lp (a)] level was measured in the next day early morning .The results of coronary angiography was determined by two experienced physicians in theDepartment of Cardiology. All patients was divided into one，two，three lesions group bystenosis (≥50%) involving the left main、left anterior descending artery、circumflex artery orright coronary artery and they make quantitative analysis of coronary artery stenosis. Allpatients in accordance with the fasting glucose levels were divided into four groups. Coronaryheart disease risk factors, and lipoprotein (a) and coronary lesions was compared betweengroups using SPSS11.5 statistical software package for statistical analysis , measureme