2012—2015年成都公共卫生临床医疗中心hiv感染者i类切口手术.pdfVIP

现代药物与临床 Drugs Clinic 第 32 卷 第 4 期 2017 年 4 月 ·733 · 2012—2015 年成都市公共卫生临床医疗中心 HIV 感染者 Ｉ类切口手术抗 菌药物的使用情况分析 吕 飞，张明明，郑 莉，徐一丹，余 行 成都市公共卫生临床医疗中心 药剂科，四川 成都 610000 摘 要：目的 调查成都市公共卫生临床医疗中心 HIV 感染患者在Ｉ类切口手术中抗菌药物的使用情况，分析其用药合理 性。方法 选取成都市公共卫生临床医疗中心 2012 年 1 月—2015 年 8 月接受Ｉ类切口手术的 218 份感染 HIV 患者的病历进 行回顾性调查分析。结果 218 份病例中预防使用抗菌药物的有 138 例，其中以第 1 代头孢菌素为主；用药时间基本（98.55% ） 在术前 30 min，手术时间超过 3 h 术中均追加一剂抗菌药物；用药疗程小于 48 h 的占 77.58% ；术后6 例切口部位感染，10 例并发肺部感染。CD4 ＋值与术后感染率呈反比，同时预防性使用抗菌药物后，切口感染发生率为 2.75% 。结论 成都市公 共卫生临床医疗中心抗菌药物使用情况基本合理，但仍存在选药不合理，给药时机不恰当，用药时间偏长的问题。需要采取 相应的干预措施，规范围手术期预防抗菌药物的使用。 关键词：抗菌药物；围手术期；HIV 感染；合理用药 中图分类号：R978.1 文献标志码：A 文章编号：1674 - 5515(2016)04 - 0733 - 04 DOI: 10.7501/j.issn.1674-5515.2017.04.042 Analysis on usage of antibiotics in patients with HIV-infection undergoing type I incision surgery in Public Health Clinical Center of Chengdu from 2012 to 2015 LÜ Fei, ZHANG Ming-ming, ZHENG Li, XU Yi-dan, YU Xing Department of Pharmacy, Public Health Clinical Center of Chengdu, Chengdu 610000, China Abstract: Objective To investigate the usage of antibiotics in patients with HIV-infection undergoing type I incision surgery in Public Health Clinical Center of Chengdu, and to analyze the rationality of drug use. Methods Records (218 cases) of patients with HIV-infection undergoing type I incision surgery in Public Health Clinical Center of Chengdu from January 2012 to August 2015 were reviewed retrospectively. Results There were 138 cases of prophylactic application of antibiotics in 218 medical records. Most of antibiotics were first - generation cephalosporins. The application time of most antibiotics (98.55%) was 30 min before surgery. When the operation lasted more than 3 h, the patients were received additional medication. The constituent ratio of the course of treatment that was less than 48 h was 77.58%. Ther