cGAS的研究进展.pdfVIP

Advances in Marine Sciences 海洋科学前沿, 2017, 4(2), 61-67 Published Online June 2017 in Hans. /journal/ams /10.12677/ams.2017.42009 Advances of cGAS Jiajing Xin, Xiaomin Guo, Li Meng, Guangdong Ji* Institute of Evolution Marine Biodiversity, College of Marine Life Sciences, Ocean University of China, Qingdao Shandong nd th rd Received: May 22 , 2017; accepted: May 20 , 2017; published: Jun. 23 , 2017 Abstract cGAS (cyclic GMP-AMP synthase), a kind of nucleic acid transferase and one of the latest DNA sen- sors being found in mammals, could identify DNA in cytoplasm and produce cGAMP (cyclic GMP-AMP) to activate interferon stimulated gene (STING), then activate the type I interferon and other cytokines to execute immune function. It was found that cGAS could not only be involved in antiviral response, but also in antibacteria response. cGAS is composed of DNA binding site in N-terminal, a central catalytic domain and a conserved Mab-21 (male abnormal 21) domain in C-terminus, which belongs to MAB21 family protein. Phylogenetic analysis showed that vertebrate cGAS is derived from ancestral Mab-21 domain, which also produced cGAS-like gene through ge- nome duplication in fishes and some mammals. In this review, we discussed the recent research progress regarding the role of cGAS in immune response and its evolution scenario. Keywords cGAS, DNA Sensor, STING, Immune, Evolution cGAS的研究进展 辛佳静，郭晓敏，孟 丽，汲广东* 中国海洋大学海洋生命学院，海洋生物多样性与进化研究所，山东 青岛 收稿日期：2017年5月22 日；录用日期：2017年5月20 日；发布日期：2017年6月23 日 摘 要 环鸟苷酸-腺苷酸合成酶(cyclic GMP-AMP synthase, cGAS)是一种核酸转移酶，在哺乳动物中具有DNA 感受器的功能，能识别胞质DNA并产生cGAMP (cyclic GMP-AMP) ，激活干扰素刺激蛋白(stimulator of *通讯作者。